ENSMUSG00000063506


Mus musculus

Features
Gene ID: ENSMUSG00000063506
  
Biological name :Arhgap22
  
Synonyms : Arhgap22 / Q8BL80 / Rho GTPase activating protein 22
  
Possible biological names infered from orthology : Q7Z5H3
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 33214026
Gene end: 33369934
  
Corresponding Affymetrix probe sets: 10413951 (MoGene1.0st)   1435108_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107587
Ensembl peptide - ENSMUSP00000154002
Ensembl peptide - ENSMUSP00000154670
Ensembl peptide - ENSMUSP00000107586
Ensembl peptide - ENSMUSP00000153801
NCBI entrez gene - 239027     See in Manteia.
MGI - MGI:2443418
RefSeq - XM_017316007
RefSeq - NM_153800
RefSeq - XM_011245053
RefSeq - XM_017316004
RefSeq - XM_017316006
RefSeq - XM_006518954
RefSeq - XM_006518956
RefSeq - XM_006518957
RefSeq - XM_006518959
RefSeq - XM_006518960
RefSeq - XM_006518961
RefSeq - XM_006518962
RefSeq Peptide - NP_722495
swissprot - Q8BL80
swissprot - D3Z1Y5
Ensembl - ENSMUSG00000063506
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGAP22ENSDARG00000076434Danio rerio
 ENSGALG00000006137Gallus gallus
 Q7Z5H3ENSG00000128805Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731546
Q8BYW1 / Arhgap25 / Rho GTPase-activating protein 25 / P42331*ENSMUSG0000003004737
Srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*ENSMUSG0000003025721
Q91Z69 / Srgap1 / SLIT-ROBO Rho GTPase-activating protein 1 / Q7Z6B7*ENSMUSG0000002012120
Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...ENSMUSG0000002642518
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138917
Q3UIA2 / Arhgap17 / Rho GTPase-activating protein 17 / Q68EM7*ENSMUSG0000003076617
Q5SSM3 / Arhgap44 / Rho GTPase-activating protein 44 / Q17R89*ENSMUSG0000003338917
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243615
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG0000011606913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013023 decreased Ly6C high monocyte number "decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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