ENSMUSG00000020121


Mus musculus

Features
Gene ID: ENSMUSG00000020121
  
Biological name :Srgap1
  
Synonyms : Q91Z69 / SLIT-ROBO Rho GTPase-activating protein 1 / Srgap1
  
Possible biological names infered from orthology : Q7Z6B7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 121780991
Gene end: 122047315
  
Corresponding Affymetrix probe sets: 10372891 (MoGene1.0st)   1431719_a_at (Mouse Genome 430 2.0 Array)   1442175_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125109
Ensembl peptide - ENSMUSP00000020322
Ensembl peptide - ENSMUSP00000080389
NCBI entrez gene - 117600     See in Manteia.
MGI - MGI:2152936
RefSeq - NM_001242411
RefSeq - XM_006513140
RefSeq - NM_001081037
RefSeq Peptide - NP_001074506
RefSeq Peptide - NP_001229340
swissprot - D3YZW1
swissprot - Q91Z69
swissprot - F7D9F7
Ensembl - ENSMUSG00000020121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srgap1aENSDARG00000007461Danio rerio
 srgap1bENSDARG00000045789Danio rerio
 SRGAP1ENSGALG00000009825Gallus gallus
 Q7Z6B7ENSG00000196935Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*ENSMUSG0000003025768
Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...ENSMUSG0000002642566
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138939
Q8BL80 / Arhgap22 / Rho GTPase activating protein 22 / Q7Z5H3*ENSMUSG0000006350613
Q3UIA2 / Arhgap17 / Rho GTPase-activating protein 17 / Q68EM7*ENSMUSG0000003076612
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731512
Q5SSM3 / Arhgap44 / Rho GTPase-activating protein 44 / Q17R89*ENSMUSG0000003338912
Q8BYW1 / Arhgap25 / Rho GTPase-activating protein 25 / P42331*ENSMUSG0000003004712
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243610
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG000001160698


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035648  srGAP1/2/3, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037451  SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030336 negative regulation of cell migration IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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