ENSG00000196935


Homo sapiens

Features
Gene ID: ENSG00000196935
  
Biological name :SRGAP1
  
Synonyms : Q7Z6B7 / SLIT-ROBO Rho GTPase activating protein 1 / SRGAP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q14.2
Gene start: 63844293
Gene end: 64162221
  
Corresponding Affymetrix probe sets: 1554473_at (Human Genome U133 Plus 2.0 Array)   1555875_at (Human Genome U133 Plus 2.0 Array)   1555876_at (Human Genome U133 Plus 2.0 Array)   1569269_s_at (Human Genome U133 Plus 2.0 Array)   227484_at (Human Genome U133 Plus 2.0 Array)   233888_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000347198
Ensembl peptide - ENSP00000437948
Ensembl peptide - ENSP00000485752
NCBI entrez gene - 57522     See in Manteia.
OMIM - 606523
RefSeq - XM_011538581
RefSeq - NM_001346201
RefSeq - NM_020762
RefSeq - XM_005269042
RefSeq - XM_011538580
RefSeq Peptide - NP_001333130
RefSeq Peptide - NP_065813
swissprot - Q7Z6B7
swissprot - G5EA48
Ensembl - ENSG00000196935
  
Related genetic diseases (OMIM): 188470 - {Thyroid cancer, nonmedullary, 2}, 188470
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srgap1aENSDARG00000007461Danio rerio
 srgap1bENSDARG00000045789Danio rerio
 SRGAP1ENSGALG00000009825Gallus gallus
 Q91Z69ENSMUSG00000020121Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43295 / SRGAP3 / SLIT-ROBO Rho GTPase activating protein 3ENSG0000019622068
O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2ENSG0000026602867
P98171 / ARHGAP4 / Rho GTPase activating protein 4ENSG0000008982039
P0DJJ0 / SRGAP2C / SLIT-ROBO Rho GTPase activating protein 2CENSG0000017194333
P0DMP2 / SRGAP2B / SLIT-ROBO Rho GTPase activating protein 2BENSG0000019636922
Q17R89 / ARHGAP44 / Rho GTPase activating protein 44ENSG0000000674013
Q7Z5H3 / ARHGAP22 / Rho GTPase activating protein 22ENSG0000012880513
P42331 / ARHGAP25 / Rho GTPase activating protein 25ENSG0000016321912
Q68EM7 / ARHGAP17 / Rho GTPase activating protein 17ENSG0000014075012
Q9Y3L3 / SH3BP1 / SH3 domain binding protein 1ENSG0000010009211
Q8N264 / ARHGAP24 / Rho GTPase activating protein 24ENSG0000013863911
Z83844.3ENSG000002853048


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035648  srGAP1/2/3, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037451  SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030336 negative regulation of cell migration IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Inactivation of CDC42 and RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction






 

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