ENSG00000006740


Homo sapiens

Features
Gene ID: ENSG00000006740
  
Biological name :ARHGAP44
  
Synonyms : ARHGAP44 / Q17R89 / Rho GTPase activating protein 44
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p12
Gene start: 12789539
Gene end: 12991643
  
Corresponding Affymetrix probe sets: 205414_s_at (Human Genome U133 Plus 2.0 Array)   215232_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463905
Ensembl peptide - ENSP00000462141
Ensembl peptide - ENSP00000465509
Ensembl peptide - ENSP00000482851
Ensembl peptide - ENSP00000262444
Ensembl peptide - ENSP00000342566
Ensembl peptide - ENSP00000368994
Ensembl peptide - ENSP00000437542
NCBI entrez gene - 9912     See in Manteia.
OMIM - 617716
RefSeq - XM_005256891
RefSeq - NM_001321164
RefSeq - NM_001321166
RefSeq - NM_001321167
RefSeq - NM_001321168
RefSeq - NM_014859
RefSeq Peptide - NP_001308096
RefSeq Peptide - NP_001308097
RefSeq Peptide - NP_055674
RefSeq Peptide - NP_001308093
RefSeq Peptide - NP_001308095
swissprot - J3QQU7
swissprot - K7EK86
swissprot - E7ERK8
swissprot - F5H6L3
swissprot - J3KRS3
swissprot - Q17R89
swissprot - A0A087WZS3
Ensembl - ENSG00000006740
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap44ENSDARG00000104549Danio rerio
 si:ch211-114m9.1ENSDARG00000102424Danio rerio
 ENSGALG00000001311Gallus gallus
 Q5SSM3ENSMUSG00000033389Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q68EM7 / ARHGAP17 / Rho GTPase activating protein 17ENSG0000014075048
Q9Y3L3 / SH3BP1 / SH3 domain binding protein 1ENSG0000010009236
Z83844.3ENSG0000028530428
O43295 / SRGAP3 / SLIT-ROBO Rho GTPase activating protein 3ENSG0000019622018
O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2ENSG0000026602817
Q7Z6B7 / SRGAP1 / SLIT-ROBO Rho GTPase activating protein 1ENSG0000019693517
Q7Z5H3 / ARHGAP22 / Rho GTPase activating protein 22ENSG0000012880515
P42331 / ARHGAP25 / Rho GTPase activating protein 25ENSG0000016321915
P98171 / ARHGAP4 / Rho GTPase activating protein 4ENSG0000008982015
Q8N264 / ARHGAP24 / Rho GTPase activating protein 24ENSG0000013863915
P0DJJ0 / SRGAP2C / SLIT-ROBO Rho GTPase activating protein 2CENSG000001719436
P0DMP2 / SRGAP2B / SLIT-ROBO Rho GTPase activating protein 2BENSG000001963693


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR004148  BAR domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035021 negative regulation of Rac protein signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0098886 modification of dendritic spine IEA
 biological_processGO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031256 leading edge membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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