ENSMUSG00000033389


Mus musculus

Features
Gene ID: ENSMUSG00000033389
  
Biological name :Arhgap44
  
Synonyms : Arhgap44 / Q5SSM3 / Rho GTPase-activating protein 44
  
Possible biological names infered from orthology : Q17R89
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 65002039
Gene end: 65162961
  
Corresponding Affymetrix probe sets: 10386965 (MoGene1.0st)   1455144_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039139
Ensembl peptide - ENSMUSP00000090680
Ensembl peptide - ENSMUSP00000090681
Ensembl peptide - ENSMUSP00000115612
NCBI entrez gene - 216831     See in Manteia.
MGI - MGI:2144423
RefSeq - XM_017314452
RefSeq - NM_001099288
RefSeq - NM_175003
RefSeq - XM_006532871
RefSeq - XM_006532872
RefSeq - XM_006532873
RefSeq - XM_006532874
RefSeq Peptide - NP_001092758
RefSeq Peptide - NP_778168
swissprot - Q5SSM3
swissprot - F6T1Y2
Ensembl - ENSMUSG00000033389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap44ENSDARG00000104549Danio rerio
 si:ch211-114m9.1ENSDARG00000102424Danio rerio
 ENSGALG00000001311Gallus gallus
 Q17R89ENSG00000006740Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UIA2 / Arhgap17 / Rho GTPase-activating protein 17 / Q68EM7*ENSMUSG0000003076648
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243635
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG0000011606928
Srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*ENSMUSG0000003025718
Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...ENSMUSG0000002642518
Q91Z69 / Srgap1 / SLIT-ROBO Rho GTPase-activating protein 1 / Q7Z6B7*ENSMUSG0000002012118
Q8BL80 / Arhgap22 / Rho GTPase activating protein 22 / Q7Z5H3*ENSMUSG0000006350616
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731516
Q8BYW1 / Arhgap25 / Rho GTPase-activating protein 25 / P42331*ENSMUSG0000003004715
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR004148  BAR domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0031503 protein-containing complex localization IC
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035021 negative regulation of Rac protein signal transduction IMP
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051649 establishment of localization in cell IC
 biological_processGO:0051668 localization within membrane IC
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 biological_processGO:0098886 modification of dendritic spine IMP
 biological_processGO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031256 leading edge membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IC
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IPI


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Arhgap44Gt(RRZ340)Byg/Arhgap44+
Genetic Background: B6.129P2-Arhgap44Gt(RRZ340)Byg

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0020512 abnormal dendritic mushroom spine morphology "any structural anomaly of the dendritic spines that have a thin neck and large bulbous head" [PMID:22791026]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0020513 abnormal dendritic stubby spine morphology "any structural anomaly of the dendritic spines that have a bulbous head but lack a thin neck; these are typically prominent in postnatal development" [PMID:22791026]
Show

Allelic Composition: Ryr2tm3.1Hhv/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr