ENSMUSG00000026425


Mus musculus

Features
Gene ID: ENSMUSG00000026425
  
Biological name :Srgap2
  
Synonyms : Q91Z67 / SLIT-ROBO Rho GTPase-activating protein 2 / Srgap2
  
Possible biological names infered from orthology : O75044 / P0DJJ0 / P0DMP2 / SLIT-ROBO Rho GTPase activating protein 2B / SLIT-ROBO Rho GTPase activating protein 2C / SRGAP2B / SRGAP2C
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 131285251
Gene end: 131527352
  
Corresponding Affymetrix probe sets: 10357630 (MoGene1.0st)   1427967_at (Mouse Genome 430 2.0 Array)   1429884_at (Mouse Genome 430 2.0 Array)   1434406_at (Mouse Genome 430 2.0 Array)   1434407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095195
Ensembl peptide - ENSMUSP00000141140
Ensembl peptide - ENSMUSP00000140927
Ensembl peptide - ENSMUSP00000140910
Ensembl peptide - ENSMUSP00000140787
Ensembl peptide - ENSMUSP00000139462
Ensembl peptide - ENSMUSP00000139405
NCBI entrez gene - 14270     See in Manteia.
MGI - MGI:109605
RefSeq - XM_011247923
RefSeq - NM_001081011
RefSeq - XM_006529134
RefSeq Peptide - NP_001074480
swissprot - A0A087WNM1
swissprot - A0A087WS73
swissprot - A0A087WSQ1
swissprot - Q91Z67
swissprot - A0A087WS59
swissprot - A0A087WNR5
swissprot - A0A087WRV4
Ensembl - ENSMUSG00000026425
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0S6J3ENSDARG00000032161Danio rerio
 ENSGALG00000000816Gallus gallus
 O75044ENSG00000266028Homo sapiens
 P0DJJ0ENSG00000171943Homo sapiens
 P0DMP2ENSG00000196369Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91Z69 / Srgap1 / SLIT-ROBO Rho GTPase-activating protein 1 / Q7Z6B7*ENSMUSG0000002012167
Srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*ENSMUSG0000003025759
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138936
Q5SSM3 / Arhgap44 / Rho GTPase-activating protein 44 / Q17R89*ENSMUSG0000003338913
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731512
Q8BL80 / Arhgap22 / Rho GTPase activating protein 22 / Q7Z5H3*ENSMUSG0000006350612
Q8BYW1 / Arhgap25 / Rho GTPase-activating protein 25 / P42331*ENSMUSG0000003004711
Q3UIA2 / Arhgap17 / Rho GTPase-activating protein 17 / Q68EM7*ENSMUSG0000003076611
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243610
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG000001160699


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR030252  SLIT-ROBO Rho GTPase-activating protein 2
 IPR031160  F-BAR domain
 IPR035648  srGAP1/2/3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003363 lamellipodium assembly involved in ameboidal cell migration ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration IMP
 biological_processGO:0030336 negative regulation of cell migration IBA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISO
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0046847 filopodium assembly IDA
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0051014 actin filament severing ISO
 biological_processGO:0060996 dendritic spine development IMP
 biological_processGO:2001223 negative regulation of neuron migration ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044327 dendritic spine head ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd8a-cre)1Itan/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd8a-cre)1Itan/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd8a-cre)1Itan/0
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex






 

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