ENSMUSG00000030047


Mus musculus

Features
Gene ID: ENSMUSG00000030047
  
Biological name :Arhgap25
  
Synonyms : Arhgap25 / Q8BYW1 / Rho GTPase-activating protein 25
  
Possible biological names infered from orthology : P42331
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 87458545
Gene end: 87533259
  
Corresponding Affymetrix probe sets: 10546010 (MoGene1.0st)   1437072_at (Mouse Genome 430 2.0 Array)   1444311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068964
Ensembl peptide - ENSMUSP00000098758
Ensembl peptide - ENSMUSP00000109267
NCBI entrez gene - 232201     See in Manteia.
MGI - MGI:2443687
RefSeq - XM_017321531
RefSeq - NM_001037727
RefSeq - NM_001286610
RefSeq - NM_175476
RefSeq - XM_006505980
RefSeq - XM_017321530
RefSeq Peptide - NP_001032816
RefSeq Peptide - NP_001273539
RefSeq Peptide - NP_780685
swissprot - Q8BYW1
Ensembl - ENSMUSG00000030047
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap25ENSDARG00000061784Danio rerio
 ARHGAP25ENSGALG00000035194Gallus gallus
 P42331ENSG00000163219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BL80 / Arhgap22 / Rho GTPase activating protein 22 / Q7Z5H3*ENSMUSG0000006350640
Q8C4V1 / Arhgap24 / Rho GTPase activating protein 24 / Q8N264*ENSMUSG0000005731540
Q91Z69 / Srgap1 / SLIT-ROBO Rho GTPase-activating protein 1 / Q7Z6B7*ENSMUSG0000002012120
Srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*ENSMUSG0000003025719
Q5SSM3 / Arhgap44 / Rho GTPase-activating protein 44 / Q17R89*ENSMUSG0000003338918
Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...ENSMUSG0000002642518
Arhgap4 / Rho GTPase activating protein 4 / P98171*ENSMUSG0000003138917
Q3UIA2 / Arhgap17 / Rho GTPase-activating protein 17 / Q68EM7*ENSMUSG0000003076617
P55194 / Sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / Z83844.3*ENSMUSG0000002243615
AL592169.1 / Q9Y3L3* / SH3BP1* / Z83844.3* / SH3 domain binding protein 1*ENSMUSG0000011606913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006911 phagocytosis, engulfment ISO
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051058 negative regulation of small GTPase mediated signal transduction ISO
 cellular_componentGO:0001891 phagocytic cup ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap4e1tm1a(KOMP)Wtsi/Ap4e1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1a(KOMP)Wtsi/Wtsi

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0020213 enhanced leukocyte migration "enhanced ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV" [GOC:NV]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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