ENSG00000171943


Homo sapiens

Features
Gene ID: ENSG00000171943
  
Biological name :SRGAP2C
  
Synonyms : P0DJJ0 / SLIT-ROBO Rho GTPase activating protein 2C / SRGAP2C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p11.2
Gene start: 121184810
Gene end: 121392822
  
Corresponding Affymetrix probe sets: 1568955_at (Human Genome U133 Plus 2.0 Array)   1568957_x_at (Human Genome U133 Plus 2.0 Array)   228628_at (Human Genome U133 Plus 2.0 Array)   232095_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483477
Ensembl peptide - ENSP00000478290
NCBI entrez gene - 653464     See in Manteia.
OMIM - 614704
RefSeq - XM_017002149
RefSeq - NM_001271872
RefSeq - NM_001329984
RefSeq - XM_005277497
RefSeq - XM_005277499
RefSeq - XM_011542015
RefSeq Peptide - NP_001258801
RefSeq Peptide - NP_001316913
swissprot - A0A087X0L1
swissprot - P0DJJ0
Ensembl - ENSG00000171943
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0S6J3ENSDARG00000032161Danio rerio
 ENSGALG00000000816Gallus gallus
 Q91Z67ENSMUSG00000026425Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2ENSG0000026602898
Q7Z6B7 / SRGAP1 / SLIT-ROBO Rho GTPase activating protein 1ENSG0000019693578
O43295 / SRGAP3 / SLIT-ROBO Rho GTPase activating protein 3ENSG0000019622068
P0DMP2 / SRGAP2B / SLIT-ROBO Rho GTPase activating protein 2BENSG0000019636966
P98171 / ARHGAP4 / Rho GTPase activating protein 4ENSG0000008982045
Q17R89 / ARHGAP44 / Rho GTPase activating protein 44ENSG0000000674010
Q9Y3L3 / SH3BP1 / SH3 domain binding protein 1ENSG000001000929
Q7Z5H3 / ARHGAP22 / Rho GTPase activating protein 22ENSG000001288058
Q68EM7 / ARHGAP17 / Rho GTPase activating protein 17ENSG000001407508
Q8N264 / ARHGAP24 / Rho GTPase activating protein 24ENSG000001386397
Z83844.3ENSG000002853046
P42331 / ARHGAP25 / Rho GTPase activating protein 25ENSG000001632196


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR027267  AH/BAR domain superfamily
 IPR030252  SLIT-ROBO Rho GTPase-activating protein 2
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration IDA
 biological_processGO:0030336 negative regulation of cell migration IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051490 negative regulation of filopodium assembly IDA
 biological_processGO:0061000 negative regulation of dendritic spine development IDA
 biological_processGO:2001224 positive regulation of neuron migration IDA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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