ENSG00000089820


Homo sapiens

Features
Gene ID: ENSG00000089820
  
Biological name :ARHGAP4
  
Synonyms : ARHGAP4 / P98171 / Rho GTPase activating protein 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q28
Gene start: 153907367
Gene end: 153934999
  
Corresponding Affymetrix probe sets: 204425_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398259
Ensembl peptide - ENSP00000408656
Ensembl peptide - ENSP00000473936
Ensembl peptide - ENSP00000473840
Ensembl peptide - ENSP00000413782
Ensembl peptide - ENSP00000412437
Ensembl peptide - ENSP00000411712
Ensembl peptide - ENSP00000203786
Ensembl peptide - ENSP00000359033
Ensembl peptide - ENSP00000359045
Ensembl peptide - ENSP00000377322
Ensembl peptide - ENSP00000385042
Ensembl peptide - ENSP00000397533
Ensembl peptide - ENSP00000398019
NCBI entrez gene - 393     See in Manteia.
OMIM - 300023
RefSeq - NM_001164741
RefSeq - NM_001666
RefSeq Peptide - NP_001657
RefSeq Peptide - NP_001158213
swissprot - A0A0B4J1X7
swissprot - F8WAR0
swissprot - H7C120
swissprot - H7C2Z8
swissprot - H7C3G3
swissprot - H7C3K8
swissprot - P98171
swissprot - S4R314
swissprot - E9PCM6
swissprot - S4R352
swissprot - E7EQN5
swissprot - C9JLA8
swissprot - C9J5M2
Ensembl - ENSG00000089820
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap4aENSDARG00000039265Danio rerio
 arhgap4bENSDARG00000015003Danio rerio
 Arhgap4ENSMUSG00000031389Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43295 / SRGAP3 / SLIT-ROBO Rho GTPase activating protein 3ENSG0000019622045
Q7Z6B7 / SRGAP1 / SLIT-ROBO Rho GTPase activating protein 1ENSG0000019693543
O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2ENSG0000026602841
P0DJJ0 / SRGAP2C / SLIT-ROBO Rho GTPase activating protein 2CENSG0000017194321
P0DMP2 / SRGAP2B / SLIT-ROBO Rho GTPase activating protein 2BENSG0000019636914
Q68EM7 / ARHGAP17 / Rho GTPase activating protein 17ENSG0000014075013
Q17R89 / ARHGAP44 / Rho GTPase activating protein 44ENSG0000000674013
Q7Z5H3 / ARHGAP22 / Rho GTPase activating protein 22ENSG0000012880513
Q8N264 / ARHGAP24 / Rho GTPase activating protein 24ENSG0000013863912
Q9Y3L3 / SH3BP1 / SH3 domain binding protein 1ENSG0000010009212
P42331 / ARHGAP25 / Rho GTPase activating protein 25ENSG0000016321911
Z83844.3ENSG0000028530410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035678  srGAP4, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010764 negative regulation of fibroblast migration IEA
 biological_processGO:0030336 negative regulation of cell migration IBA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030426 growth cone IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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