ENSMUSG00000017144


Mus musculus

Features
Gene ID: ENSMUSG00000017144
  
Biological name :Rnd3
  
Synonyms : P61588 / Rho-related GTP-binding protein RhoE / Rnd3
  
Possible biological names infered from orthology : P61587 / Rho family GTPase 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.1
Gene start: 51130438
Gene end: 51149111
  
Corresponding Affymetrix probe sets: 10482500 (MoGene1.0st)   1416700_at (Mouse Genome 430 2.0 Array)   1416701_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128831
Ensembl peptide - ENSMUSP00000017288
NCBI entrez gene - 74194     See in Manteia.
MGI - MGI:1921444
RefSeq - NM_028810
RefSeq Peptide - NP_083086
swissprot - E9Q8D7
swissprot - P61588
Ensembl - ENSMUSG00000017144
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnd3aENSDARG00000076799Danio rerio
 rnd3bENSDARG00000007396Danio rerio
 RND3ENSGALG00000026313Gallus gallus
 RND3ENSG00000115963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnd2 / Q9QYM5 / Rho family GTPase 2 / P52198*ENSMUSG0000000131359
Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*ENSMUSG0000005485559
4930544G11Rik / RIKEN cDNA 4930544G11 geneENSMUSG0000003646339
Rhoa / Q9QUI0 / ras homolog family member A / P61586*ENSMUSG0000000781539
Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*ENSMUSG0000000223339
Rhob / P62746 / ras homolog family member B / P62745*ENSMUSG0000005436438
Rhof / Q8BYP3 / ras homolog family member F (in filopodia) / Q9HBH0* / ras homolog family member F, filopodia associated*ENSMUSG0000002944935
Rhod / P97348 / ras homolog family member D / O00212*ENSMUSG0000004184532


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0000440 domed skull 
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002200 abnormal brain ventricle/choroid plexus morphology "malformation or absence of the brain ventricles or their associated choroid plexuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002958 aqueductal stenosis "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005356 positive geotaxis "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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