ENSMUSG00000041498


Mus musculus

Features
Gene ID: ENSMUSG00000041498
  
Biological name :Kif14
  
Synonyms : Kif14 / Kinesin-like protein KIF14 / L0N7N1
  
Possible biological names infered from orthology : kinesin family member 14 / Q15058
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 136466343
Gene end: 136531511
  
Corresponding Affymetrix probe sets: 10350297 (MoGene1.0st)   10350329 (MoGene1.0st)   1445525_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142040
Ensembl peptide - ENSMUSP00000144265
Ensembl peptide - ENSMUSP00000044257
Ensembl peptide - ENSMUSP00000139698
NCBI entrez gene - 381293     See in Manteia.
MGI - MGI:1098226
RefSeq - XM_011248046
RefSeq - XM_006529730
RefSeq - XM_011248039
RefSeq - XM_011248040
RefSeq - XM_011248043
RefSeq - XM_011248044
RefSeq - NM_001287179
RefSeq - XM_006529729
RefSeq Peptide - NP_001274108
swissprot - L0N759
swissprot - L0N7N1
swissprot - A0A0J9YUN5
swissprot - E9Q3T3
Ensembl - ENSMUSG00000041498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif14ENSDARG00000062187Danio rerio
 KIF14ENSGALG00000002175Gallus gallus
 KIF14ENSG00000118193Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif13a / kinesin family member 13A / Q9H1H9*ENSMUSG0000002137523
Kif13b / kinesin family member 13B / Q9NQT8*ENSMUSG0000006001223
Kif1b / Q60575 / Kinesin-like protein KIF1B / O60333* / kinesin family member 1B*ENSMUSG0000006307722
Kif1a / kinesin family member 1A / Q12756*ENSMUSG0000001460221
Q80TF6 / Stard9 / StAR-related lipid transfer protein 9 / Q9P2P6* / StAR related lipid transfer domain containing 9*ENSMUSG0000003370520
B1AVY7 / Kif16b / Kinesin-like protein KIF16B / Q96L93* / kinesin family member 16B*ENSMUSG0000003884420
Kif1c / O35071 / Kinesin-like protein KIF1C / O43896* / kinesin family member 1C*ENSMUSG0000002082118
Kif28ENSMUSG0000008723615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001752  Kinesin motor domain
 IPR008984  SMAD/FHA domain superfamily
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR032405  Kinesin-associated
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0021685 cerebellar granular layer structural organization IMP
 biological_processGO:0021693 cerebellar Purkinje cell layer structural organization IMP
 biological_processGO:0021695 cerebellar cortex development IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030155 regulation of cell adhesion ISO
 biological_processGO:0030334 regulation of cell migration ISO
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031641 regulation of myelination IMP
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0032487 regulation of Rap protein signal transduction ISO
 biological_processGO:0033624 negative regulation of integrin activation ISO
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0051301 cell division IMP
 biological_processGO:1903429 regulation of cell maturation IMP
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0051233 spindle midzone IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IDA
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030165 PDZ domain binding ISO


Pathways (from Reactome)
Pathway description
RHO GTPases activate CIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ergtm1.2Iwamo/Ergtm1.2Iwamo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0006221 optic nerve hypoplasia "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0010012 ectopic cerebral cortex pyramidal cells "the cerebral cortex pyramidal cell body resides in places other than the pyramidal cell layer of the cerebral cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Kif14lag/Kif14lag
Genetic Background: B6.D2(129X1)-Kif14lag

 MP:0012174 flat head "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [MGI:anna]
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Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000038943 Prc1 / Q99K43 / protein regulator of cytokinesis 1 / O43663*  / reaction / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction






 

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