ENSMUSG00000014602


Mus musculus

Features
Gene ID: ENSMUSG00000014602
  
Biological name :Kif1a
  
Synonyms : Kif1a / kinesin family member 1A
  
Possible biological names infered from orthology : Q12756
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 93015464
Gene end: 93101951
  
Corresponding Affymetrix probe sets: 10356712 (MoGene1.0st)   1421053_at (Mouse Genome 430 2.0 Array)   1450108_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128432
Ensembl peptide - ENSMUSP00000108582
Ensembl peptide - ENSMUSP00000130717
Ensembl peptide - ENSMUSP00000141194
Ensembl peptide - ENSMUSP00000140656
Ensembl peptide - ENSMUSP00000140163
Ensembl peptide - ENSMUSP00000139403
Ensembl peptide - ENSMUSP00000084029
NCBI entrez gene - 16560     See in Manteia.
MGI - MGI:108391
RefSeq - XM_017318289
RefSeq - NM_001110315
RefSeq - NM_001294149
RefSeq - NM_001294150
RefSeq - NM_008440
RefSeq - XM_006529155
RefSeq - XM_006529156
RefSeq - XM_006529157
RefSeq - XM_006529158
RefSeq - XM_006529159
RefSeq - XM_006529160
RefSeq - XM_006529161
RefSeq Peptide - NP_001281078
RefSeq Peptide - NP_001281079
RefSeq Peptide - NP_032466
RefSeq Peptide - NP_001103785
swissprot - A0A087WRJ3
swissprot - G3UW47
swissprot - A0A087WQE8
swissprot - Q6TA13
swissprot - A0A087WNM0
swissprot - E9QAN4
swissprot - E9Q9G6
swissprot - A0A087WSU7
Ensembl - ENSMUSG00000014602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif1aaENSDARG00000061817Danio rerio
 kif1cENSDARG00000062024Danio rerio
 KIF1AENSGALG00000006221Gallus gallus
 KIF1AENSG00000130294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif1b / Q60575 / Kinesin-like protein KIF1B / O60333* / kinesin family member 1B*ENSMUSG0000006307773
Kif1c / O35071 / Kinesin-like protein KIF1C / O43896* / kinesin family member 1C*ENSMUSG0000002082135
Kif13b / kinesin family member 13B / Q9NQT8*ENSMUSG0000006001230
Kif13a / kinesin family member 13A / Q9H1H9*ENSMUSG0000002137530
Q80TF6 / Stard9 / StAR-related lipid transfer protein 9 / Q9P2P6* / StAR related lipid transfer domain containing 9*ENSMUSG0000003370523
B1AVY7 / Kif16b / Kinesin-like protein KIF16B / Q96L93* / kinesin family member 16B*ENSMUSG0000003884422
Kif14 / L0N7N1 / Kinesin-like protein KIF14 / Q15058* / kinesin family member 14*ENSMUSG0000004149821
Kif28ENSMUSG0000008723618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001752  Kinesin motor domain
 IPR001849  Pleckstrin homology domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR019821  Kinesin motor domain, conserved site
 IPR022140  Kinesin-like KIF1-type
 IPR022164  Kinesin-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR032405  Kinesin-associated
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0008089 anterograde axonal transport IEA
 biological_processGO:0022027 interkinetic nuclear migration IEA
 biological_processGO:0098840 protein transport along microtubule IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Kif1algdg/Kif1algdg
Genetic Background: C3.Cg-Kif1algdg/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif1algdg/Kif1algdg
Genetic Background: C3.Cg-Kif1algdg/GrsrJ

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif1algdg/Kif1algdg
Genetic Background: C3.Cg-Kif1algdg/GrsrJ

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0004793 abnormal synaptic vesicle clustering "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kif1algdg/Kif1algdg
Genetic Background: C3.Cg-Kif1algdg/GrsrJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Kif1algdg/Kif1algdg
Genetic Background: C3.Cg-Kif1algdg/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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