ENSMUSG00000063077


Mus musculus

Features
Gene ID: ENSMUSG00000063077
  
Biological name :Kif1b
  
Synonyms : Kif1b / Kinesin-like protein KIF1B / Q60575
  
Possible biological names infered from orthology : kinesin family member 1B / O60333
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 149176319
Gene end: 149307693
  
Corresponding Affymetrix probe sets: 10518585 (MoGene1.0st)   1423994_at (Mouse Genome 430 2.0 Array)   1423995_at (Mouse Genome 430 2.0 Array)   1425270_at (Mouse Genome 430 2.0 Array)   1451200_at (Mouse Genome 430 2.0 Array)   1451642_at (Mouse Genome 430 2.0 Array)   1451762_a_at (Mouse Genome 430 2.0 Array)   1455182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030806
Ensembl peptide - ENSMUSP00000056754
Ensembl peptide - ENSMUSP00000061472
Ensembl peptide - ENSMUSP00000120076
NCBI entrez gene - 16561     See in Manteia.
MGI - MGI:108426
RefSeq - XM_011250200
RefSeq - XM_006538591
RefSeq - XM_006538592
RefSeq - XM_006538593
RefSeq - XM_006538594
RefSeq - XM_006538595
RefSeq - XM_006538596
RefSeq - NM_001290995
RefSeq - NM_008441
RefSeq - NM_207682
RefSeq - XM_006538590
RefSeq Peptide - NP_997565
RefSeq Peptide - NP_001277924
RefSeq Peptide - NP_032467
swissprot - F6XNB6
swissprot - Q60575
swissprot - A2AH75
Ensembl - ENSMUSG00000063077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif1bENSDARG00000037020Danio rerio
 KIF1BENSGALG00000002726Gallus gallus
 KIF1BENSG00000054523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kif1a / kinesin family member 1A / Q12756*ENSMUSG0000001460268
Kif1c / O35071 / Kinesin-like protein KIF1C / O43896* / kinesin family member 1C*ENSMUSG0000002082132
Kif13b / kinesin family member 13B / Q9NQT8*ENSMUSG0000006001228
Kif13a / kinesin family member 13A / Q9H1H9*ENSMUSG0000002137528
Q80TF6 / Stard9 / StAR-related lipid transfer protein 9 / Q9P2P6* / StAR related lipid transfer domain containing 9*ENSMUSG0000003370523
Kif14 / L0N7N1 / Kinesin-like protein KIF14 / Q15058* / kinesin family member 14*ENSMUSG0000004149820
B1AVY7 / Kif16b / Kinesin-like protein KIF16B / Q96L93* / kinesin family member 16B*ENSMUSG0000003884420
Kif28ENSMUSG0000008723617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001752  Kinesin motor domain
 IPR001849  Pleckstrin homology domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011993  PH-like domain superfamily
 IPR019821  Kinesin motor domain, conserved site
 IPR022140  Kinesin-like KIF1-type
 IPR022164  Kinesin-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR032405  Kinesin-associated
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007270 neuron-neuron synaptic transmission IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0009792 embryo development ending in birth or egg hatching NAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010970 transport along microtubule IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport IDA
 biological_processGO:0032418 lysosome localization IEA
 biological_processGO:0047497 mitochondrion transport along microtubule IDA
 biological_processGO:1904647 response to rotenone IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990778 protein localization to cell periphery IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IBA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:1990939 ATP-dependent microtubule motor activity IEA


Pathways (from Reactome)
Pathway description
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
Show

Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tshz1tm1Garr/Tshz1tm2.2Garr
Genetic Background: mixed

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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