ENSG00000086061


Homo sapiens

Features
Gene ID: ENSG00000086061
  
Biological name :DNAJA1
  
Synonyms : DNAJA1 / DnaJ heat shock protein family (Hsp40) member A1 / P31689
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p21.1
Gene start: 33025211
Gene end: 33039907
  
Corresponding Affymetrix probe sets: 200880_at (Human Genome U133 Plus 2.0 Array)   200881_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369127
NCBI entrez gene - 3301     See in Manteia.
OMIM - 602837
RefSeq - NM_001539
RefSeq - NM_001314039
RefSeq Peptide - NP_001300968
RefSeq Peptide - NP_001530
swissprot - P31689
Ensembl - ENSG00000086061
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnaja1ENSDARG00000030972Danio rerio
 DNAJA1ENSGALG00000023066Gallus gallus
 Dnaja1ENSMUSG00000028410Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4ENSG0000014040374
DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2ENSG0000006934557
Q9UBS4 / DNAJB11 / DnaJ heat shock protein family (Hsp40) member B11ENSG0000009052031
AC068631.2ENSG0000028314914


Protein motifs (from Interpro)
Interpro ID Name
 IPR001305  Heat shock protein DnaJ, cysteine-rich domain
 IPR001623  DnaJ domain
 IPR002939  Chaperone DnaJ, C-terminal
 IPR008971  HSP40/DnaJ peptide-binding
 IPR012724  Chaperone DnaJ
 IPR018253  DnaJ domain, conserved site
 IPR036410  Heat shock protein DnaJ, cysteine-rich domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006986 response to unfolded protein TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0042769 DNA damage response, detection of DNA damage IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043508 negative regulation of JUN kinase activity IMP
 biological_processGO:0051223 regulation of protein transport IDA
 biological_processGO:0070585 protein localization to mitochondrion IMP
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1903748 negative regulation of establishment of protein localization to mitochondrion IDA
 biological_processGO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098554 cytoplasmic side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0001671 ATPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IDA
 molecular_functionGO:0030957 Tat protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IDA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IPI


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / reaction / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / reaction / complex
 ENSG00000086061 DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1  / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction






 

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