ENSG00000069345


Homo sapiens

Features
Gene ID: ENSG00000069345
  
Biological name :DNAJA2
  
Synonyms : DNAJA2 / DnaJ heat shock protein family (Hsp40) member A2 / O60884
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q11.2
Gene start: 46955362
Gene end: 46973788
  
Corresponding Affymetrix probe sets: 209157_at (Human Genome U133 Plus 2.0 Array)   226994_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000314030
Ensembl peptide - ENSP00000477579
Ensembl peptide - ENSP00000460104
NCBI entrez gene - 10294     See in Manteia.
OMIM - 611322
RefSeq - NM_005880
RefSeq Peptide - NP_005871
swissprot - O60884
swissprot - I3L320
swissprot - A0A024R6S1
swissprot - A0A087WT48
Ensembl - ENSG00000069345
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnaja2ENSDARG00000104066Danio rerio
 dnaja2lENSDARG00000010745Danio rerio
 DNAJA2ENSGALG00000004115Gallus gallus
 Dnaja2ENSMUSG00000031701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1ENSG0000008606155
DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4ENSG0000014040353
Q9UBS4 / DNAJB11 / DnaJ heat shock protein family (Hsp40) member B11ENSG0000009052032
AC068631.2ENSG0000028314913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001305  Heat shock protein DnaJ, cysteine-rich domain
 IPR001623  DnaJ domain
 IPR002939  Chaperone DnaJ, C-terminal
 IPR008971  HSP40/DnaJ peptide-binding
 IPR012724  Chaperone DnaJ
 IPR018253  DnaJ domain, conserved site
 IPR036410  Heat shock protein DnaJ, cysteine-rich domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0042026 protein refolding IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001671 ATPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051087 chaperone binding IPI


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / reaction / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / reaction / complex
 ENSG00000069345 DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2  / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction






 

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