ENSG00000140403


Homo sapiens

Features
Gene ID: ENSG00000140403
  
Biological name :DNAJA4
  
Synonyms : DNAJA4 / DnaJ heat shock protein family (Hsp40) member A4 / Q8WW22
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q25.1
Gene start: 78264086
Gene end: 78282196
  
Corresponding Affymetrix probe sets: 1554333_at (Human Genome U133 Plus 2.0 Array)   1554334_a_at (Human Genome U133 Plus 2.0 Array)   220395_at (Human Genome U133 Plus 2.0 Array)   225061_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441946
Ensembl peptide - ENSP00000443962
Ensembl peptide - ENSP00000339581
Ensembl peptide - ENSP00000378321
Ensembl peptide - ENSP00000378324
Ensembl peptide - ENSP00000395191
Ensembl peptide - ENSP00000407136
Ensembl peptide - ENSP00000413499
Ensembl peptide - ENSP00000438263
NCBI entrez gene - 55466     See in Manteia.
RefSeq - XM_006720601
RefSeq - NM_001130182
RefSeq - NM_001130183
RefSeq - NM_018602
RefSeq - XM_005254535
RefSeq Peptide - NP_061072
RefSeq Peptide - NP_001123654
RefSeq Peptide - NP_001123655
swissprot - F5H300
swissprot - F8WF76
swissprot - F5GWV1
swissprot - F5H170
swissprot - Q8WW22
swissprot - C9JDE6
Ensembl - ENSG00000140403
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DNAJA4ENSDARG00000051762Danio rerio
 DNAJA4ENSGALG00000036850Gallus gallus
 Dnaja4ENSMUSG00000032285Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1ENSG0000008606169
DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2ENSG0000006934552
Q9UBS4 / DNAJB11 / DnaJ heat shock protein family (Hsp40) member B11ENSG0000009052029
AC068631.2ENSG0000028314912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001305  Heat shock protein DnaJ, cysteine-rich domain
 IPR001623  DnaJ domain
 IPR002939  Chaperone DnaJ, C-terminal
 IPR008971  HSP40/DnaJ peptide-binding
 IPR012724  Chaperone DnaJ
 IPR018253  DnaJ domain, conserved site
 IPR036410  Heat shock protein DnaJ, cysteine-rich domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0042026 protein refolding IDA
 biological_processGO:0090084 negative regulation of inclusion body assembly IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding IDA
 molecular_functionGO:0051087 chaperone binding IPI


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / reaction / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000140403 DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4  / complex
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / complex / reaction






 

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