ENSMUSG00000025321


Mus musculus

Features
Gene ID: ENSMUSG00000025321
  
Biological name :Itgb8
  
Synonyms : integrin subunit beta 8 / Itgb8
  
Possible biological names infered from orthology : P26012
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F2
Gene start: 119158022
Gene end: 119238802
  
Corresponding Affymetrix probe sets: 10403229 (MoGene1.0st)   1436223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026360
NCBI entrez gene - 320910     See in Manteia.
MGI - MGI:1338035
RefSeq - NM_177290
RefSeq Peptide - NP_796264
swissprot - Q0VBD0
Ensembl - ENSMUSG00000025321
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb8ENSDARG00000028222Danio rerio
 ITGB8ENSGALG00000010875Gallus gallus
 ITGB8ENSG00000105855Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*ENSMUSG0000002697134
Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*ENSMUSG0000002068934
Itgb5 / integrin subunit beta 5 / P18084*ENSMUSG0000002281734
Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*ENSMUSG0000002580932
Itgb2 / P05107* / integrin subunit beta 2*ENSMUSG0000000029031
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128130
Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*ENSMUSG0000002075828
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015726
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG0000003292515


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR015442  Integrin beta-8 subunit
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001573 ganglioside metabolic process IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051216 cartilage development IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034686 integrin alphav-beta8 complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:1990430 extracellular matrix protein binding IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agttm1Afu/Agttm1Afu,Tg(Fabp4-Agt)2Mte/0
Genetic Background: involves: C57BL/6 * CBA * DBA/2 * ICR

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
Show

Allelic Composition: Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: C3H * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr