ENSMUSG00000022817


Mus musculus

Features
Gene ID: ENSMUSG00000022817
  
Biological name :Itgb5
  
Synonyms : integrin subunit beta 5 / Itgb5
  
Possible biological names infered from orthology : P18084
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 33829665
Gene end: 33949153
  
Corresponding Affymetrix probe sets: 10435305 (MoGene1.0st)   1417533_a_at (Mouse Genome 430 2.0 Array)   1417534_at (Mouse Genome 430 2.0 Array)   1456133_x_at (Mouse Genome 430 2.0 Array)   1456195_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069416
Ensembl peptide - ENSMUSP00000110680
NCBI entrez gene - 16419     See in Manteia.
MGI - MGI:96614
RefSeq - NM_001145884
RefSeq - NM_010580
RefSeq Peptide - NP_001139356
RefSeq Peptide - NP_034710
swissprot - Q6PE70
swissprot - G5E8F8
Ensembl - ENSMUSG00000022817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb5ENSDARG00000012942Danio rerio
 ITGB5ENSGALG00000029766Gallus gallus
 ITGB5ENSG00000082781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*ENSMUSG0000002068951
Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*ENSMUSG0000002697146
Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*ENSMUSG0000002580939
Itgb2 / P05107* / integrin subunit beta 2*ENSMUSG0000000029035
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128135
Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*ENSMUSG0000002075832
Itgb8 / integrin subunit beta 8 / P26012*ENSMUSG0000002532131
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015728
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG0000003292515


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027067  Integrin beta-5 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034684 integrin alphav-beta5 complex IEA
 cellular_componentGO:0043235 receptor complex IEA


Pathways (from Reactome)
Pathway description
Cross-presentation of particulate exogenous antigens (phagosomes)
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Srrtm1.2Jtc/Srr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex






 

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