MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Dmp1tm1Mis/Dmp1tm1.1Mis Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0000128 | growth retardation of molars | "developmental delay of the growth of the molars" [J:17489] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0000133 | abnormal long bone metaphysis morphology | "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Dmp1tm1Mis/Dmp1tm1.1Mis Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0000165 | abnormal hypertrophic chondrocyte zone | "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0000168 | abnormal bone marrow development | "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gsdma3Mhdaclp1/Gsdma3+ Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1
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MP:0000195 | hypocalcemia | "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0000198 | hypophosphatemia | "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0000259 | abnormal vascular development | "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509] |
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Allelic Composition: Gsdma3Mhdaclp1/Gsdma3+ Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1
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MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gsdma3Mhdaclp1/Gsdma3+ Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1
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MP:0002136 | abnormal kidney physiology | "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gsdma3Mhdaclp1/Gsdma3+ Genetic Background: C3HeB/FeJ-Gsdma3Mhdaclp1
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0002577 | reduced enamel thickness | "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0002817 | abnormal tooth mineralization | "abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0002818 | abnormal dentin morphology | "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0002819 | abnormal pulp cavity morphology | "defects in the central hollow space of a tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0002904 | increased circulating parathyroid hormone level | "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0002998 | abnormal bone remodeling | "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0003109 | short femur | "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd
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MP:0003116 | rickets | "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0003668 | abnormal periodontal ligament morphology | "any structural anomaly in the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66512] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Dmp1tm1Mis/Dmp1tm1.1Mis Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0004189 | abnormal alveolar process | "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0004988 | increased osteoblast cell number | "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0006400 | decreased molar number | "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0008151 | increased diameter of long bones | "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0008753 | abnormal osteocyte morphology | "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0009445 | osteomalacia | "gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0010868 | increased bone trabecula number | "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0010926 | increased osteoid volume | "increase in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0011584 | increased alkaline phosphatase activity | "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035] |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0011712 | absent osteoblast differentiation | |
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Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0011721 | abnormal bone mineralization involved in bone maturation | "anomaly in the deposition of calcium phosphate in bone tissue, involved in the progression of the developing skeleton from its formation to its mature state" [GO:0035630] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030131 | abnormal periodontium morphology | "any structural anomaly of the specialized tissues that both surround and support the teeth, maintaining them in the maxillary and mandibular bones; it consists of four principal components: the gums (gingiva), periodontal ligament, cementum, and alveolar bone proper" [https://en.wikipedia.org/wiki/Periodontium] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030451 | abnormal dentin mineralization | "anomaly in the process by which calcium salts are deposited into dentin" [GO:0097188] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030452 | abnormal cementum mineralization | "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum" [GO:0071529] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030466 | alveolar process atrophy | "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030484 | abnormal osteocyte lacuna morphology | "any structural anomaly of the small cavity within the bone matrix that is occupied by an osteocyte cell body, and from which slender canaliculi radiate and penetrate the adjacent lamellae to anastomose with the canaliculi of neighboring lacunae, thus forming a system of cavities interconnected by minute canals" [https://medical-dictionary.thefreedictionary.com/osteocyte+lacuna] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0030485 | abnormal osteocyte lacunocanalicular system morphology | "any structural anomaly of the large network intercommunicating the lacunae and canaliculi which contain the osteocytes and their cytoplasmic processes within the mineralized bone matrix" [PMID:22928392] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
Allelic Composition: Dmp1tm1Mis/Dmp1tm1Mis Genetic Background: involves: 129S7/SvEvBrd * CD-1
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MP:0030486 | abnormal osteocyte canaliculus morphology | "any structural anomaly of the slender canals situated between the lacunae of ossified bone where osteocyte cytoplasmic (dendritic) processes reside; osteocyte canaliculi are used for exchange of nutrients and waste products through gap junctions" [https://en.wikipedia.org/wiki/Bone_canaliculus, https://en.wikipedia.org/wiki/Osteocyte] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030540 | misaligned teeth | "abnormal alignment, positioning, or spacing of the teeth" [HP:0000692] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030542 | abnormal dentin development | "any anomaly in the process whose specific outcome is the formation of dentin, the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root; dentinogenesis begins prior to enamel formation and is initiated by the odontoblasts of the dental pulp; dentin is derived from the dental papilla of the tooth germ; after apposition of predentin and maturation into dentin, the cell bodies of the odontoblasts remain in the pulp inside the tooth, along its outer wall; unlike enamel, dentin continues to form throughout life and can be initiated in response to stimuli, such as tooth decay or attrition" [GO:0097187, https://en.wikipedia.org/wiki/Dentin] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030543 | abnormal predentin morphology | "any structural anomaly of the initial type I collagen-rich unmineralized extracellular matrix synthesized and secreted by odontoblasts and located at the dentin-pulp interface; predentin is converted to dentin when hydroxyapatite crystals are deposited on the predentin" [https://books.google.com/books?isbn=0470958332] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030545 | abnormal acellular cementum morphology | "any structural anomaly of the acellular layer of cementum, a living tissue that does not incorporate cells (cementocytes) into its structure, consisting only of extracellular matrix components and mineral; acellular cementum is the first cementum deposited on the dentin of the forming root, and is predominantly found on the cervical/coronal portion of the tooth root; it anchors the primary collagen fibers of the periodontal ligament, providing a strong attachment between the tooth and surrounding alveolar bone" [http://www.7med-pdf.com/1020q/13530-structure-of-cementum.html, https://en.wikipedia.org/wiki/Cementum, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030546 | abnormal cellular cementum morphology | "any structural anomaly of the layer of cementum that contains cementocytes in lacunae; it is most abundant on the apical portion of the tooth root and in the furcation areas of multirooted teeth, and has a role in posteruptive adjustment of tooth position" [http://dental.pitt.edu/periohistology-glossary, http://www.7med-pdf.com/1020q/13530-structure-of-cementum.html, https://en.wikipedia.org/wiki/Cementum, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030549 | abnormal cementocyte lacunocanalicular system morphology | "any structural anomaly of the osteocyte-like network of lacunae and canaliculi housing the cementocytes and their cytoplasmic processes within the cellular cementum; although cementocytes resemble osteocytes, they show profound differences in terms of dendrite number, lacunar shape, and canalicular network density, suggesting less communication between, to, and from cementocytes compared with osteocytes" [PMID:26274352, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030550 | abnormal cementoblast morphology | "any structural anomaly of the large cuboidal cells differentiated from fibroblasts of the dental follicle (or possibly from Hertwig’s epithelial root sheath cells by epithelial-mesenchymal transformation) that, during formation of cellular cementum, secrete a layer of unmineralized extracellular matrix called cementoid; as cementoid deposition progresses, some cementoblasts become embedded in cementoid matrix and become cementocytes" [https://books.google.com/books?isbn=1118342917, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030552 | decreased cementoblast number | "fewer than the expected number of the large cuboidal cells differentiated from fibroblasts of the dental follicle (or possibly from Hertwig’s epithelial root sheath cells by epithelial-mesenchymal transformation) that, during formation of cellular cementum, secrete a layer of unmineralized extracellular matrix called cementoid; as cementoid deposition progresses, some cementoblasts become embedded in cementoid matrix and become cementocytes" [MGI:anna] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030555 | abnormal cementocyte lacuna morphology | "any structural anomaly of the small cavity within the cellular cementum that is occupied by a cementocyte cell body; cementocyte lacunae are described as larger and more irregular in size and shape (from oval to tubular) and with rougher walls than the typical ellipsoid osteocyte lacunae; occasionally, empty lacunae or lacunae containing more than one cell are observed in cellular cementum, not typically observed in osteocyte lacunae" [PMID:26274352, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030556 | abnormal cementocyte canaliculus morphology | "any structural anomaly of the slender canals situated between lacunae of the cellular cementum where cementocyte cytoplasmic (dendritic) processes reside; cementocyte canaliculi appear to be less organized, more sparse, and do they radiate outward, with the majority of them oriented toward the vascular periodontal ligament for nutrition, unlike osteocyte canaliculi which are radiating, more dense and arranged in a complex network" [https://books.google.com/books?isbn=8131238016, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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MP:0030557 | abnormal cementocyte dendritic process morphology | "any structural anomaly of the long, slender cytoplasmic processes that extend from the cementocyte cell body, run along narrow canaliculi, and are linked to neighboring cementocytes processes via gap junctions; cementocytes harbor fewer dendritic processes than osteocytes" [https://books.google.com/books?isbn=8131238016, PMID:27029548] |
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Allelic Composition: L1camtm1.1Vlem/L1camtm1.1Vlem Genetic Background: B6.Cg-L1camtm1.1Vlem
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