ENSG00000184371


Homo sapiens

Features
Gene ID: ENSG00000184371
  
Biological name :CSF1
  
Synonyms : colony stimulating factor 1 / CSF1 / P09603
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.3
Gene start: 109910242
Gene end: 109930992
  
Corresponding Affymetrix probe sets: 207082_at (Human Genome U133 Plus 2.0 Array)   209716_at (Human Genome U133 Plus 2.0 Array)   210557_x_at (Human Genome U133 Plus 2.0 Array)   211839_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358817
Ensembl peptide - ENSP00000407317
Ensembl peptide - ENSP00000434527
Ensembl peptide - ENSP00000433837
Ensembl peptide - ENSP00000431547
Ensembl peptide - ENSP00000327513
Ensembl peptide - ENSP00000349854
Ensembl peptide - ENSP00000358816
NCBI entrez gene - 1435     See in Manteia.
OMIM - 120420
RefSeq - XM_017000369
RefSeq - NM_000757
RefSeq - NM_172210
RefSeq - NM_172211
RefSeq - NM_172212
RefSeq Peptide - NP_757350
RefSeq Peptide - NP_000748
RefSeq Peptide - NP_757349
RefSeq Peptide - NP_757351
swissprot - H7BY18
swissprot - E9PKP4
swissprot - P09603
swissprot - E9PQ08
swissprot - E9PJA2
Ensembl - ENSG00000184371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CSF1ENSGALG00000033854Gallus gallus
 Csf1ENSMUSG00000014599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008001  Macrophage colony stimulating factor-1
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002158 osteoclast proliferation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003006 developmental process involved in reproduction ISS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010743 regulation of macrophage derived foam cell differentiation NAS
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IDA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030097 hemopoiesis NAS
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0030225 macrophage differentiation TAS
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030316 osteoclast differentiation IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IDA
 biological_processGO:0032946 positive regulation of mononuclear cell proliferation IDA
 biological_processGO:0038145 macrophage colony-stimulating factor signaling pathway IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042117 monocyte activation NAS
 biological_processGO:0042488 positive regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045657 positive regulation of monocyte differentiation ISS
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060611 mammary gland fat development IEA
 biological_processGO:0060763 mammary duct terminal end bud growth IEA
 biological_processGO:1902228 positive regulation of macrophage colony-stimulating factor signaling pathway IDA
 biological_processGO:1904141 positive regulation of microglial cell migration IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1990682 CSF1-CSF1R complex IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005157 macrophage colony-stimulating factor receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Other interleukin signaling
Interleukin-10 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157368 IL34 / Q6ZMJ4 / interleukin 34  / complex / reaction
 ENSG00000182578 CSF1R / P07333 / colony stimulating factor 1 receptor  / complex






 

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