12978


Mus musculus (NCBI)
regulationproteinkinaseactivitycellbindingphosphorylationreceptortyrosinesignalingresponsedifferentiationfactormembraneprocesstransmembranepathwayproliferationmacrophagecolony-stimulatingimmunedevelopmentosteoclastcellularstimuluscascadeerkcytokineplasmaintegral

Features
Gene ID: 12978
  
Biological name :
  
Synonyms : AI323359|CD115|CSF-1R|Csfmr|Fim-2|Fim2|Fms|M-CSF-R|M-CSFR / colony stimulating factor 1 receptor / Csf1r
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1419872_at (Mouse Genome 430 2.0 Array)   1419873_s_at (Mouse Genome 430 2.0 Array)   1423593_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - NC_000084.6
RefSeq - 126723423
RefSeq - XP_006525647.1
RefSeq - XP_006525648.1
RefSeq - XP_006525649.1
RefSeq - XP_017173299.1
RefSeq - 1039755536
RefSeq - 569003140
RefSeq - NP_001032948.2
RefSeq - 569003142
RefSeq - 569003144
RefSeq - XR_001782332.1
RefSeq - NM_001037859.2
RefSeq - NM_007779.2
RefSeq - XM_006525584.1
RefSeq - XM_006525585.3
RefSeq - XM_006525586.3
RefSeq - XM_017317810.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000024621 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stresscell communicationcellular response to stimulusanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processregulation of biological qualitylocalization of cellregulation of molecular functioncell deathimmune responsetissue remodelingmacromolecule localizationestablishment of localizationcytokine productionactin filament-based processnitrognitrogen compound metabolic processcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processresponresponse to stresscell ccell communicationcellulcellular response to stimulusanatomanatomical structure developmentresponresponse to external stimuluscellulcellular component organizationresponresponse to chemicalmovememovement of cell or subcellular componentcellulcellular developmental processregularegulation of biological qualitylocalilocalization of cellregularegulation of molecular functioncell dcell deathimmuneimmune responsetissuetissue remodelingmacrommacromolecule localizationestablestablishment of localizationcytokicytokine productionactin actin filament-based process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingdrug bindingorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingcatalytic acticatalytic activity, acting on a proteintransferase actransferase activitysignaling recesignaling receptor activityprotein bindinprotein bindingion bindingion bindingcarbohydrate dcarbohydrate derivative bindingdrug bindingdrug binding
cellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008283 cell proliferation ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0019221 cytokine-mediated signaling pathway ISO
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0030097 hemopoiesis ISO
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031529 ruffle organization IMP
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus ISO
 biological_processGO:0038145 macrophage colony-stimulating factor signaling pathway IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045124 regulation of bone resorption ISO
 biological_processGO:0045217 cell-cell junction maintenance ISO
 biological_processGO:0045672 positive regulation of osteoclast differentiation ISO
 biological_processGO:0046488 phosphatidylinositol metabolic process IMP
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:0090197 positive regulation of chemokine secretion ISO
 biological_processGO:2000147 positive regulation of cell motility ISO
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0043235 receptor complex IBA
 cellular_componentGO:1990682 CSF1-CSF1R complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005011 macrophage colony-stimulating factor receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IBA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019955 cytokine binding ISO
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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