ENSG00000163435


Homo sapiens

Features
Gene ID: ENSG00000163435
  
Biological name :ELF3
  
Synonyms : E74 like ETS transcription factor 3 / ELF3 / P78545
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 202007945
Gene end: 202017188
  
Corresponding Affymetrix probe sets: 201510_at (Human Genome U133 Plus 2.0 Array)   210827_s_at (Human Genome U133 Plus 2.0 Array)   229842_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405162
Ensembl peptide - ENSP00000352673
Ensembl peptide - ENSP00000356252
Ensembl peptide - ENSP00000356253
NCBI entrez gene - 1999     See in Manteia.
OMIM - 602191
RefSeq - XM_005244942
RefSeq - NM_001114309
RefSeq - NM_004433
RefSeq Peptide - NP_001107781
RefSeq Peptide - NP_004424
swissprot - P78545
swissprot - Q5SR36
swissprot - A0A024R974
Ensembl - ENSG00000163435
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elf3ENSDARG00000077982Danio rerio
 ELF3ENSGALG00000000616Gallus gallus
 Elf3ENSMUSG00000003051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EHF / Q9NZC4 / ETS homologous factorENSG0000013537332
ELF5 / Q9UKW6 / E74 like ETS transcription factor 5ENSG0000013537423
ELF2 / Q15723 / E74 like ETS transcription factor 2ENSG0000010938119
ELF1 / P32519 / E74 like ETS transcription factor 1ENSG0000012069019
ELF4 / Q99607 / E74 like ETS transcription factor 4ENSG0000010203418
ETV6 / P41212 / ETS variant 6ENSG0000013908318
SPDEF / O95238 / SAM pointed domain containing ETS transcription factorENSG0000012466418
ETV7 / Q9Y603 / ETS variant 7ENSG0000001003016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR033074  ETS-related transcription factor Elf-3
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008544 epidermis development NAS
 biological_processGO:0009653 anatomical structure morphogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060056 mammary gland involution ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / reaction






 

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