ENSMUSG00000003051


Mus musculus

Features
Gene ID: ENSMUSG00000003051
  
Biological name :Elf3
  
Synonyms : Elf3 / ETS-related transcription factor Elf-3 / Q3UPW2
  
Possible biological names infered from orthology : E74 like ETS transcription factor 3 / P78545
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 135253575
Gene end: 135258568
  
Corresponding Affymetrix probe sets: 10358027 (MoGene1.0st)   1416916_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003135
Ensembl peptide - ENSMUSP00000139769
NCBI entrez gene - 13710     See in Manteia.
MGI - MGI:1101781
RefSeq - XM_006529125
RefSeq - NM_001163131
RefSeq - NM_007921
RefSeq - XM_006529124
RefSeq Peptide - NP_001156603
RefSeq Peptide - NP_031947
swissprot - Q3UPW2
Ensembl - ENSMUSG00000003051
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elf3ENSDARG00000077982Danio rerio
 ELF3ENSGALG00000000616Gallus gallus
 ELF3ENSG00000163435Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ehf / O70273 / ETS homologous factor / Q9NZC4*ENSMUSG0000001235031
Elf5 / Q8VDK3 / ETS-related transcription factor Elf-5 / Q9UKW6* / E74 like ETS transcription factor 5*ENSMUSG0000002718624
Elf2 / Q9JHC9 / ETS-related transcription factor Elf-2 / Q15723* / E74 like ETS transcription factor 2*ENSMUSG0000003717419
Elf1 / Q60775 / ETS-related transcription factor Elf-1 / P32519* / E74 like ETS transcription factor 1*ENSMUSG0000003646118
Elf4 / Q9Z2U4 / ETS-related transcription factor Elf-4 / Q99607* / E74 like ETS transcription factor 4*ENSMUSG0000003110317
Etv6 / P97360 / Transcription factor ETV6 / P41212* / ETS variant 6*ENSMUSG0000003019917
Spdef / Q9WTP3 / SAM pointed domain-containing Ets transcription factor / O95238*ENSMUSG0000002421517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR033074  ETS-related transcription factor Elf-3
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009653 anatomical structure morphogenesis IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030855 epithelial cell differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060056 mammary gland involution IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Vdrtm1.1Gcm/Vdrtm1.1Gcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / reaction






 

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