ENSMUSG00000027186


Mus musculus

Features
Gene ID: ENSMUSG00000027186
  
Biological name :Elf5
  
Synonyms : Elf5 / ETS-related transcription factor Elf-5 / Q8VDK3
  
Possible biological names infered from orthology : E74 like ETS transcription factor 5 / Q9UKW6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E2
Gene start: 103411688
Gene end: 103450989
  
Corresponding Affymetrix probe sets: 10474171 (MoGene1.0st)   1419555_at (Mouse Genome 430 2.0 Array)   1419556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028609
Ensembl peptide - ENSMUSP00000118565
Ensembl peptide - ENSMUSP00000126941
Ensembl peptide - ENSMUSP00000131940
NCBI entrez gene - 13711     See in Manteia.
MGI - MGI:1335079
RefSeq - XM_006498705
RefSeq - NM_001145813
RefSeq - NM_010125
RefSeq - XM_006498704
RefSeq Peptide - NP_034255
RefSeq Peptide - NP_001139285
swissprot - Q3V1F7
swissprot - Q8VDK3
swissprot - A2AL22
Ensembl - ENSMUSG00000027186
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ELF5ENSGALG00000035867Gallus gallus
 ELF5ENSG00000135374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ehf / O70273 / ETS homologous factor / Q9NZC4*ENSMUSG0000001235046
Elf3 / Q3UPW2 / ETS-related transcription factor Elf-3 / P78545* / E74 like ETS transcription factor 3*ENSMUSG0000000305138
Etv6 / P97360 / Transcription factor ETV6 / P41212* / ETS variant 6*ENSMUSG0000003019923
Spdef / Q9WTP3 / SAM pointed domain-containing Ets transcription factor / O95238*ENSMUSG0000002421521
Elf2 / Q9JHC9 / ETS-related transcription factor Elf-2 / Q15723* / E74 like ETS transcription factor 2*ENSMUSG0000003717420
Elf4 / Q9Z2U4 / ETS-related transcription factor Elf-4 / Q99607* / E74 like ETS transcription factor 4*ENSMUSG0000003110319
Elf1 / Q60775 / ETS-related transcription factor Elf-1 / P32519* / E74 like ETS transcription factor 1*ENSMUSG0000003646118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR033069  ETS-related transcription factor Elf-5
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001712 ectodermal cell fate commitment IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

Allelic Composition: Elf5tm1Sin/Elf5+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: A/A,U/U
Genetic Background: Not Specified

Allelic Composition: Elf5tm1Sin/Elf5+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Itga8tm1.1Rdav/Itga8tm1.1Rdav,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

Allelic Composition: Elf5tm1Plp/Elf5tm1Plp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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