ENSMUSG00000031103


Mus musculus

Features
Gene ID: ENSMUSG00000031103
  
Biological name :Elf4
  
Synonyms : Elf4 / ETS-related transcription factor Elf-4 / Q9Z2U4
  
Possible biological names infered from orthology : E74 like ETS transcription factor 4 / Q99607
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A5
Gene start: 48411046
Gene end: 48463132
  
Corresponding Affymetrix probe sets: 10604393 (MoGene1.0st)   1421337_at (Mouse Genome 430 2.0 Array)   1421338_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033429
Ensembl peptide - ENSMUSP00000110608
Ensembl peptide - ENSMUSP00000118436
NCBI entrez gene - 56501     See in Manteia.
MGI - MGI:1928377
RefSeq - XM_006541527
RefSeq - NM_019680
RefSeq - XM_006541526
RefSeq Peptide - NP_062654
swissprot - Q9Z2U4
swissprot - Q3U1U8
Ensembl - ENSMUSG00000031103
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elf1ENSDARG00000020759Danio rerio
 ELF4ENSG00000102034Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elf1 / Q60775 / ETS-related transcription factor Elf-1 / P32519* / E74 like ETS transcription factor 1*ENSMUSG0000003646135
Elf2 / Q9JHC9 / ETS-related transcription factor Elf-2 / Q15723* / E74 like ETS transcription factor 2*ENSMUSG0000003717429
Etv6 / P97360 / Transcription factor ETV6 / P41212* / ETS variant 6*ENSMUSG0000003019910
Elf3 / Q3UPW2 / ETS-related transcription factor Elf-3 / P78545* / E74 like ETS transcription factor 3*ENSMUSG0000000305110
Spdef / Q9WTP3 / SAM pointed domain-containing Ets transcription factor / O95238*ENSMUSG0000002421510
Ehf / O70273 / ETS homologous factor / Q9NZC4*ENSMUSG000000123508
Elf5 / Q8VDK3 / ETS-related transcription factor Elf-5 / Q9UKW6* / E74 like ETS transcription factor 5*ENSMUSG000000271867


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR022084  Transcription factor Elf, N-terminal
 IPR033070  ETS-related transcription factor Elf-4
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001787 natural killer cell proliferation IDA
 biological_processGO:0001866 NK T cell proliferation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0002220 large lymphoid organs "increased size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Dstdt-J/Dstdt-J
Genetic Background: C3HeB/FeJ-Dstdt-J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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