ENSMUSG00000024215


Mus musculus

Features
Gene ID: ENSMUSG00000024215
  
Biological name :Spdef
  
Synonyms : Q9WTP3 / SAM pointed domain-containing Ets transcription factor / Spdef
  
Possible biological names infered from orthology : O95238
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 27714352
Gene end: 27728951
  
Corresponding Affymetrix probe sets: 10449377 (MoGene1.0st)   1450220_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025054
Ensembl peptide - ENSMUSP00000110520
Ensembl peptide - ENSMUSP00000117743
Ensembl peptide - ENSMUSP00000127056
NCBI entrez gene - 30051     See in Manteia.
MGI - MGI:1353422
RefSeq - XM_017317499
RefSeq - NM_013891
RefSeq - XM_006524379
RefSeq - XM_006524380
RefSeq - XM_006524381
RefSeq Peptide - NP_001344657
RefSeq Peptide - NP_038919
swissprot - B2KF87
swissprot - Q9WTP3
Ensembl - ENSMUSG00000024215
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPDEFENSDARG00000029930Danio rerio
 SPDEFENSG00000124664Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Etv6 / P97360 / Transcription factor ETV6 / P41212* / ETS variant 6*ENSMUSG0000003019923
Elf2 / Q9JHC9 / ETS-related transcription factor Elf-2 / Q15723* / E74 like ETS transcription factor 2*ENSMUSG0000003717421
Elf4 / Q9Z2U4 / ETS-related transcription factor Elf-4 / Q99607* / E74 like ETS transcription factor 4*ENSMUSG0000003110320
Elf3 / Q3UPW2 / ETS-related transcription factor Elf-3 / P78545* / E74 like ETS transcription factor 3*ENSMUSG0000000305120
Elf1 / Q60775 / ETS-related transcription factor Elf-1 / P32519* / E74 like ETS transcription factor 1*ENSMUSG0000003646120
Ehf / O70273 / ETS homologous factor / Q9NZC4*ENSMUSG0000001235018
Elf5 / Q8VDK3 / ETS-related transcription factor Elf-5 / Q9UKW6* / E74 like ETS transcription factor 5*ENSMUSG0000002718616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010454 negative regulation of cell fate commitment IMP
 biological_processGO:0010455 positive regulation of cell fate commitment IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060480 lung goblet cell differentiation IDA
 biological_processGO:0060576 intestinal epithelial cell development IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0002241 abnormal laryngeal mucosa goblet cell morphology "any structural anomaly of the epithelial cells lining the larynx, which produce mucins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

 MP:0010790 abnormal stomach pyloric antrum morphology "any structrual anomaly of the area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0010863 absent respiratory mucosa goblet cells "absence of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Rpe65450L/Rpe65450L
Genetic Background: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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