ENSG00000124664


Homo sapiens

Features
Gene ID: ENSG00000124664
  
Biological name :SPDEF
  
Synonyms : O95238 / SAM pointed domain containing ETS transcription factor / SPDEF
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.31
Gene start: 34537802
Gene end: 34556333
  
Corresponding Affymetrix probe sets: 213441_x_at (Human Genome U133 Plus 2.0 Array)   213442_x_at (Human Genome U133 Plus 2.0 Array)   214403_x_at (Human Genome U133 Plus 2.0 Array)   214404_x_at (Human Genome U133 Plus 2.0 Array)   220192_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363149
Ensembl peptide - ENSP00000442715
NCBI entrez gene - 25803     See in Manteia.
OMIM - 608144
RefSeq - XM_005248988
RefSeq - NM_001252294
RefSeq - NM_012391
RefSeq Peptide - NP_036523
RefSeq Peptide - NP_001239223
swissprot - O95238
Ensembl - ENSG00000124664
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPDEFENSDARG00000029930Danio rerio
 SpdefENSMUSG00000024215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETV6 / P41212 / ETS variant 6ENSG0000013908322
ELF4 / Q99607 / E74 like ETS transcription factor 4ENSG0000010203420
ETV7 / Q9Y603 / ETS variant 7ENSG0000001003020
ELF3 / P78545 / E74 like ETS transcription factor 3ENSG0000016343520
ELF1 / P32519 / E74 like ETS transcription factor 1ENSG0000012069019
ELF2 / Q15723 / E74 like ETS transcription factor 2ENSG0000010938119
EHF / Q9NZC4 / ETS homologous factorENSG0000013537317
ELF5 / Q9UKW6 / E74 like ETS transcription factor 5ENSG0000013537416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0010454 negative regulation of cell fate commitment IEA
 biological_processGO:0010455 positive regulation of cell fate commitment IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060480 lung goblet cell differentiation IEA
 biological_processGO:0060576 intestinal epithelial cell development IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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