ENSMUSG00000028402


Mus musculus

Features
Gene ID: ENSMUSG00000028402
  
Biological name :Mpdz
  
Synonyms : Mpdz / multiple PDZ domain protein / Q8VBX6
  
Possible biological names infered from orthology : multiple PDZ domain crumbs cell polarity complex component / O75970
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C3
Gene start: 81278500
Gene end: 81442815
  
Corresponding Affymetrix probe sets: 10514000 (MoGene1.0st)   1418663_at (Mouse Genome 430 2.0 Array)   1418664_at (Mouse Genome 430 2.0 Array)   1441361_at (Mouse Genome 430 2.0 Array)   1442978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116830
Ensembl peptide - ENSMUSP00000116767
Ensembl peptide - ENSMUSP00000118283
Ensembl peptide - ENSMUSP00000152533
Ensembl peptide - ENSMUSP00000122498
Ensembl peptide - ENSMUSP00000122308
Ensembl peptide - ENSMUSP00000099894
Ensembl peptide - ENSMUSP00000102879
Ensembl peptide - ENSMUSP00000102883
NCBI entrez gene - 17475     See in Manteia.
MGI - MGI:1343489
RefSeq - XM_011249940
RefSeq - NM_001305284
RefSeq - NM_001305286
RefSeq - NM_010820
RefSeq - XM_006537643
RefSeq - XM_006537644
RefSeq - XM_006537646
RefSeq - XM_006537647
RefSeq - XM_006537649
RefSeq - XM_006537650
RefSeq Peptide - NP_034950
RefSeq Peptide - NP_001292215
RefSeq Peptide - NP_001292213
swissprot - A3KG84
swissprot - F7D0H8
swissprot - I7HJS5
swissprot - A3KG83
swissprot - Q8VBX6
swissprot - A3KG82
swissprot - D3YUX2
swissprot - B2RQR2
Ensembl - ENSMUSG00000028402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-92j12.5ENSDARG00000094677Danio rerio
 MPDZENSGALG00000005846Gallus gallus
 MPDZENSG00000107186Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Patj / Q63ZW7 / Mus musculus PATJ, crumbs cell polarity complex component (Patj), transcript variant 5, mRNA. / Q8NI35* / PATJ, crumbs cell polarity complex component*ENSMUSG0000006185937
Pdzd2 / PDZ domain containing 2 / O15018*ENSMUSG0000002219715
Il16 / O54824 / Pro-interleukin-16 Interleukin-16 / Q14005* / interleukin 16*ENSMUSG0000000174110
Pard3 / Q99NH2 / par-3 family cell polarity regulator / Q8TEW0*ENSMUSG0000002581210
Pard3b / Q9CSB4 / par-3 family cell polarity regulator beta / Q8TEW8*ENSMUSG000000520629
Lnx2 / Q91XL2 / Ligand of Numb protein X 2 / Q8N448*ENSMUSG000000165207
Lnx1 / O70263 / ligand of numb-protein X 1 / Q8TBB1*ENSMUSG000000292286


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR015132  L27-2
 IPR032078  Multiple PDZ domain protein
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002570 alcohol aversion 
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009775 increased behavioral withdrawal response "increase in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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