ENSMUSG00000028063


Mus musculus

Features
Gene ID: ENSMUSG00000028063
  
Biological name :Lmna
  
Synonyms : Lmna / P48678 / Prelamin-A/C Lamin-A/C
  
Possible biological names infered from orthology : lamin A/C / P02545
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 88480147
Gene end: 88509956
  
Corresponding Affymetrix probe sets: 10499394 (MoGene1.0st)   1421654_a_at (Mouse Genome 430 2.0 Array)   1425472_a_at (Mouse Genome 430 2.0 Array)   1426868_x_at (Mouse Genome 430 2.0 Array)   1452212_at (Mouse Genome 430 2.0 Array)   1457670_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029699
Ensembl peptide - ENSMUSP00000040265
Ensembl peptide - ENSMUSP00000113093
Ensembl peptide - ENSMUSP00000120784
NCBI entrez gene - 16905     See in Manteia.
MGI - MGI:96794
RefSeq - XM_006501073
RefSeq - NM_001002011
RefSeq - NM_001111102
RefSeq - NM_019390
RefSeq Peptide - NP_001002011
RefSeq Peptide - NP_001104572
RefSeq Peptide - NP_062263
swissprot - P48678
swissprot - D3YUF7
Ensembl - ENSMUSG00000028063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmnaENSDARG00000013415Danio rerio
 ENSGALG00000006083Gallus gallus
 LMNAENSG00000160789Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmnb1 / P14733 / Lamin-B1 / P20700*ENSMUSG0000002459048
Lmnb2 / P21619 / Lamin-B2 / Q03252*ENSMUSG0000006207547
Nefm / neurofilament medium / P07197*ENSMUSG0000002205422
Prph / peripherin / P41219*ENSMUSG0000002348420
Des / P31001 / Desmin / P17661*ENSMUSG0000002620819
Gfap / P03995 / Glial fibrillary acidic protein / P14136*ENSMUSG0000002093219
Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*ENSMUSG0000002205519
Vim / P20152 / vimentin / P08670*ENSMUSG0000002672818
Nefh / P19246 / Neurofilament heavy polypeptide / P12036* / neurofilament heavy*ENSMUSG0000002039618
Ina / P46660 / internexin neuronal intermediate filament protein, alpha / Q16352*ENSMUSG0000003433618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001322  Lamin tail domain
 IPR001664  Intermediate filament protein
 IPR018039  Intermediate filament protein, conserved site
 IPR036415  Lamin tail domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0006998 nuclear envelope organization ISO
 biological_processGO:0007517 muscle organ development ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030010 establishment of cell polarity NAS
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030951 establishment or maintenance of microtubule cytoskeleton polarity IMP
 biological_processGO:0032204 regulation of telomere maintenance ISO
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:0034613 cellular protein localization ISO
 biological_processGO:0035105 obsolete sterol regulatory element binding protein import into nucleus IMP
 biological_processGO:0055015 ventricular cardiac muscle cell development IMP
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation IMP
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0090343 positive regulation of cell aging ISO
 biological_processGO:1900180 regulation of protein localization to nucleus IMP
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005638 lamin filament IDA
 cellular_componentGO:0005652 nuclear lamina IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000021 prominent ears "protuberant outer ears" [J:61768]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000469 abnormal esophageal squamous epithelium morphology "malformation of the scaly epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lmnatm1.2Yxz/Lmnatm1.2Yxz
Genetic Background: involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm11Lgf/Lmnatm11Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: PfasSofa-5J/Pfas+
Genetic Background: B6(129S1)-PfasSofa-5J/GrsrJ

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
Show

Allelic Composition: PfasSofa-5J/Pfas+
Genetic Background: B6(129S1)-PfasSofa-5J/GrsrJ

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1.2Yxz/Lmnatm1.2Yxz
Genetic Background: involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wrntm1Lgu/Wrntm1Lgu
Genetic Background: B6J.Cg-Wrntm1Lgu

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: NMRI

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: Not Specified

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmnatm1Stw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm11Lgf/Lmnatm11Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mlip+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: Not Specified

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wrntm1Lgu/Wrntm1Lgu
Genetic Background: B6J.Cg-Wrntm1Lgu

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Lmnatm2Lgf/Lmnatm2Lgf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Otin/Lmnatm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Yxz/Lmnatm1.1Yxz
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: LmnaGt(S7-1F1)Sor/Lmna+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0002251 abnormal nasopharynx morphology "structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Stw/Lmna+
Genetic Background: involves: 129S1/Sv

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmna+,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmna+,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003081 abnormal soleus morphology "anomaly in the the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003082 abnormal gastrocnemius morphology "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Stw/Lmna+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm7Lgf/Lmnatm7Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm7Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2Lgf/Lmnatm7Lgf
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm7Lgf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lmnatm8Lgf/Lmnatm8Lgf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0003159 abnormal esophageal smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003330 abnormal auditory tube "anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003756 abnormal hard palate "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003841 abnormal lambdoidal suture morphology "malformation of the articulation of the parietal bones and the occipital bone" [Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0003916 decreased left ventricle weight "less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm8Lgf/Lmnatm8Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003978 decreased circulating carnitine level "lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0004469 abnormal zygomatic arch morphology "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0004675 rib fractures "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm4Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004680 small xiphoid process "reduced size of the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmna+,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mliptm1.1(cre)Dzw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1Lgf/Lmnatm1Stw
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm8Lgf/Lmnatm8Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006018 abnormal tympanic membrane morphology "any structural alterations in the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane consitutes the boundary between the external and middle ear." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:46639:]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0006197 ocular hypotelorism "the distance between the eyes is reduced" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0006213 shallow orbits "decrease in the depth of the orbit" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0008012 duodenal polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0008244 abnormal peritoneal macrophage morphology "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0008526 decreased skull width "having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm5Lgf/Lmnatm5Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0008890 abnormal nuclear lamina morphology "alteration in the structure of the inner nuclear membrane surrounding the nuclear periphery, comprising a scaffold-like network of protein filaments responsible for trafficking of mRNA to the cytoplasm" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009388 abnormal epidermal melanocyte morphology "any structural anomaly of the cells that produce pigment in the epidermis" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1.2Yxz/Lmnatm1.2Yxz
Genetic Background: involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0009415 skeletal muscle degeneration "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0009416 cardiac muscle degeneration "pathological deterioration of cardiac muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009536 abnormal interstitial cell of Cajal morphology "any structural abnormality in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise; abnormalities in the ICC network can cause chronic intestinal pseudo-obstruction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:16460275]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0009871 abnormal aorta tunica adventitia morphology "any structural anomaly of the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nbeal2gps/Nbeal2gps
Genetic Background: 129S1/SvImJ-Nbeal2gps

 MP:0009878 decreased susceptibility to bone fracture "reduced probability that injury or disease will result in damaged or broken bones" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0010031 abnormal cranium size "deviation from the average range of cranium size compared to normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0010043 abnormal frontonasal suture morphology "any structural anomaly of the dense, fibrous connective tissue joint between the frontal and nasal bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010520 sinoatrial block "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010522 aorta calcification "pathologic deposition of calcium salts in the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010523 thoracic aorta calcification "pathologic deposition of calcium salts in the part of the aorta that extends from the origin at the heart to the diaphragm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010524 aortic arch calcification "pathologic deposition of calcium salts in the convex portion of the aorta between the ascending and descending parts of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Lmnatm1Rben/Lmnatm1Rben
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmnatm2.1Gbon
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lmnatm1.2Yxz/Lmnatm1.2Yxz
Genetic Background: involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011570 esophageal achalasia "failure of the normal relaxation of the lower esophageal sphincter associated with the uncoordinated contractions of the thoracic esophagus, resulting in functional obstruction" [ISBN:0-683-40008-8]
Show

Allelic Composition: Lmnatm11Lgf/Lmna+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Lmnatm2.1Gbon/Lmna+
Genetic Background: involves: 129 * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0013192 decreased sebaceous gland number "fewer than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts" [MGI:anna]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0013193 sebaceous gland hypoplasia "underdevelopment and decreased size of the sebum secreting glands of the hair shaft, usually due to a decrease in the number of cells" [MGI:anna]
Show

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0013458 decreased eccrine gland number "fewer than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present " [MGI:Anna]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0020084 short ears "reduced length of the ears" [GOC:NV]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: LmnaDhe/LmnaDhe
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0020324 jejunum polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the jejunum" [ORCID: orcid.org/0000-0003-4606-0597, PMID:25578479]
Show

Allelic Composition: Lmnatm4Stw/Lmnatm4Stw,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: C57BL/6J

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Lmnatm1Lgf/Lmnatm1Lgf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030080 small lower incisors "reduced size of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030090 short upper incisors "reduced length of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0030160 abnormal auditory bulla morphology "any structural anomaly of the hollow bony structure on the ventral, posterior portion of the skull that encloses parts of the middle and inner ear; in most species, it is formed by the tympanic part of the temporal bone" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0030413 tympanic membrane retraction "a condition in which a segment of the tympanic membrane (eardrum) collapses inwards towards the middle ear space and lies more medially (deeper) than its normal position; the retracted segment is often known as a retraction pocket" [http://allearseducation.org/resources/Tutorial-10-Retractions.pdf, https://en.wikipedia.org/wiki/Tympanic_membrane_retraction]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / reaction
 ENSMUSG00000028063 Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*  / - / complex
 ENSMUSG00000001964 Emd / O08579 / Emerin / P50402*  / complex
 ENSMUSG00000027997 Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*  / reaction
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000052889 Prkcb / P68404 / protein kinase C, beta / P05771*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr