ENSMUSG00000022054


Mus musculus

Features
Gene ID: ENSMUSG00000022054
  
Biological name :Nefm
  
Synonyms : Nefm / neurofilament medium
  
Possible biological names infered from orthology : P07197
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 68082590
Gene end: 68124846
  
Corresponding Affymetrix probe sets: 10421100 (MoGene1.0st)   1422520_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022638
Ensembl peptide - ENSMUSP00000106718
NCBI entrez gene - 18040     See in Manteia.
MGI - MGI:97314
RefSeq - NM_008691
RefSeq Peptide - NP_032717
swissprot - D3YZ35
swissprot - A0A0R4J036
Ensembl - ENSMUSG00000022054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nefmaENSDARG00000021351Danio rerio
 nefmbENSDARG00000043697Danio rerio
 NEFMENSGALG00000000317Gallus gallus
 NEFMENSG00000104722Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nefh / P19246 / Neurofilament heavy polypeptide / P12036* / neurofilament heavy*ENSMUSG0000002039637
Ina / P46660 / internexin neuronal intermediate filament protein, alpha / Q16352*ENSMUSG0000003433627
Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*ENSMUSG0000002205527
Prph / peripherin / P41219*ENSMUSG0000002348422
Vim / P20152 / vimentin / P08670*ENSMUSG0000002672822
Gfap / P03995 / Glial fibrillary acidic protein / P14136*ENSMUSG0000002093221
Des / P31001 / Desmin / P17661*ENSMUSG0000002620821
Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*ENSMUSG0000002806317
Lmnb2 / P21619 / Lamin-B2 / Q03252*ENSMUSG0000006207516
Lmnb1 / P14733 / Lamin-B1 / P20700*ENSMUSG0000002459015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR002957  Keratin, type I
 IPR006821  Intermediate filament head, DNA-binding domain
 IPR018039  Intermediate filament protein, conserved site
 IPR027697  Neurofilament medium polypeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0061564 axon development IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005883 neurofilament IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 cellular_componentGO:0097418 neurofibrillary tangle IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nefhtm1Ral/Nefhtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj,Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Pdgfratm1Sor/Pdgfratm7Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj,Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * C57BL/6

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj,Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inatm1Jpj/Inatm1Jpj,Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nefmtm1Mvr/Nefmtm1Mvr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefhtm2Dwc/Nefhtm2Dwc,Nefmtm1Mvr/Nefmtm1Mvr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj,Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nefmtm1Jpj/Nefmtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nefmtm1Mvr/Nefmtm1Mvr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefhtm2Dwc/Nefhtm2Dwc,Nefmtm1Mvr/Nefmtm1Mvr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefmtm1Ral/Nefmtm1Ral
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Swiss Webster)

Allelic Composition: Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefhtm1Ral/Nefhtm1Ral,Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefmtm1Dwc/Nefmtm1Dwc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefhtm1Ral/Nefhtm1Ral,Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Nefmtm1Mvr/Nefmtm1Mvr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nefmtm1Milg/Nefmtm1Milg
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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