ENSMUSG00000020932


Mus musculus

Features
Gene ID: ENSMUSG00000020932
  
Biological name :Gfap
  
Synonyms : Gfap / Glial fibrillary acidic protein / P03995
  
Possible biological names infered from orthology : P14136
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 102887336
Gene end: 102900912
  
Corresponding Affymetrix probe sets: 10391798 (MoGene1.0st)   1426508_at (Mouse Genome 430 2.0 Array)   1426509_s_at (Mouse Genome 430 2.0 Array)   1440142_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064691
Ensembl peptide - ENSMUSP00000077061
NCBI entrez gene - 14580     See in Manteia.
MGI - MGI:95697
RefSeq - NM_001131020
RefSeq - NM_010277
RefSeq Peptide - NP_001124492
RefSeq Peptide - NP_034407
swissprot - P03995
Ensembl - ENSMUSG00000020932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfapENSDARG00000025301Danio rerio
 GFAPENSGALG00000000909Gallus gallus
 GFAPENSG00000131095Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vim / P20152 / vimentin / P08670*ENSMUSG0000002672857
Des / P31001 / Desmin / P17661*ENSMUSG0000002620856
Prph / peripherin / P41219*ENSMUSG0000002348452
Ina / P46660 / internexin neuronal intermediate filament protein, alpha / Q16352*ENSMUSG0000003433645
Nefm / neurofilament medium / P07197*ENSMUSG0000002205442
Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*ENSMUSG0000002205542
Nefh / P19246 / Neurofilament heavy polypeptide / P12036* / neurofilament heavy*ENSMUSG0000002039637
Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*ENSMUSG0000002806330
Lmnb1 / P14733 / Lamin-B1 / P20700*ENSMUSG0000002459029
Lmnb2 / P21619 / Lamin-B2 / Q03252*ENSMUSG0000006207529


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR006821  Intermediate filament head, DNA-binding domain
 IPR018039  Intermediate filament protein, conserved site
 IPR027701  Glial fibrillary acidic protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010625 positive regulation of Schwann cell proliferation IMP
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0014002 astrocyte development IGI
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0031102 neuron projection regeneration IMP
 biological_processGO:0045103 intermediate filament-based process IMP
 biological_processGO:0045109 intermediate filament organization ISS
 biological_processGO:0051580 regulation of neurotransmitter uptake IMP
 biological_processGO:0060020 Bergmann glial cell differentiation IMP
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:1904714 regulation of chaperone-mediated autophagy IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005882 intermediate filament IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISO
 cellular_componentGO:0097386 glial cell projection IDA
 cellular_componentGO:0097449 astrocyte projection ISO
 cellular_componentGO:0097450 astrocyte end-foot IDA
 cellular_componentGO:0098574 cytoplasmic side of lysosomal membrane IEA
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005198 structural molecule activity IMP
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gfaptm2Mes/Gfap+,Tg(GFAP)10Mes/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm3Ito/Gfaptm3Ito
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Gfaptm4Ito/Gfaptm4Ito,Vimtm1Cba/Vimtm1Cba
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ddx4tm1Tnc/Ddx4tm1Tnc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gfaptm2Mes/Gfaptm2Mes
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gfaptm3Mes/Gfaptm3Mes
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0001893 non-obstructive hydrocephaly "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfap+,Tg(GFAP)10Mes/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gfaptm1Mes/Gfaptm1Mes
Genetic Background: either: (involves: 129S7/SvEvBrd * 129X1/SvJ) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gfaptm3Mes/Gfaptm3Mes
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm3Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfaptm2Mes
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfap+,Tg(GFAP)10Mes/0
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm3Ito/Gfaptm3Ito
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Gfaptm4Ito/Gfaptm4Ito
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Gfaptm4Ito/Gfaptm4Ito,Vimtm1Cba/Vimtm1Cba
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm3Mes/Gfaptm3Mes
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm3Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfaptm2Mes
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002807 abnormal eye blink conditioning behavior "defects in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an airpuff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Gfaptm1Mes/Gfaptm1Mes
Genetic Background: either: (involves: 129S7/SvEvBrd * 129X1/SvJ) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gfaptm1Mes/Gfaptm1Mes
Genetic Background: either: (involves: 129S7/SvEvBrd * 129X1/SvJ) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008811 abnormal brain iron level "any anomaly in the amount of iron present in the brain tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfaptm2Mes/Gfap+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
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Allelic Composition: Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0012506 brain atrophy "acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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