ENSMUSG00000024590


Mus musculus

Features
Gene ID: ENSMUSG00000024590
  
Biological name :Lmnb1
  
Synonyms : Lamin-B1 / Lmnb1 / P14733
  
Possible biological names infered from orthology : P20700
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: D3
Gene start: 56707813
Gene end: 56753424
  
Corresponding Affymetrix probe sets: 10455813 (MoGene1.0st)   1423520_at (Mouse Genome 430 2.0 Array)   1423521_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025486
NCBI entrez gene - 16906     See in Manteia.
MGI - MGI:96795
RefSeq - NM_010721
RefSeq Peptide - NP_034851
swissprot - P14733
Ensembl - ENSMUSG00000024590
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmnb1ENSDARG00000044299Danio rerio
 LMNB1ENSGALG00000014692Gallus gallus
 LMNB1ENSG00000113368Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmnb2 / P21619 / Lamin-B2 / Q03252*ENSMUSG0000006207556
Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*ENSMUSG0000002806355
Des / P31001 / Desmin / P17661*ENSMUSG0000002620822
Nefm / neurofilament medium / P07197*ENSMUSG0000002205422
Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*ENSMUSG0000002205522
Gfap / P03995 / Glial fibrillary acidic protein / P14136*ENSMUSG0000002093221
Nefh / P19246 / Neurofilament heavy polypeptide / P12036* / neurofilament heavy*ENSMUSG0000002039621
Prph / peripherin / P41219*ENSMUSG0000002348421
Ina / P46660 / internexin neuronal intermediate filament protein, alpha / Q16352*ENSMUSG0000003433620
Vim / P20152 / vimentin / P08670*ENSMUSG0000002672820


Protein motifs (from Interpro)
Interpro ID Name
 IPR001322  Lamin tail domain
 IPR001664  Intermediate filament protein
 IPR018039  Intermediate filament protein, conserved site
 IPR036415  Lamin tail domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle NAS
 biological_processGO:0046330 positive regulation of JNK cascade NAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005637 nuclear inner membrane IDA
 cellular_componentGO:0005638 lamin filament IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0008432 JUN kinase binding NAS
 molecular_functionGO:0043274 phospholipase binding IPI


Pathways (from Reactome)
Pathway description
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Breakdown of the nuclear lamina
Depolymerisation of the Nuclear Lamina


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-78H/Oca2p-78H
Genetic Background: involves: C3H/HeH

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001184 absent alveoli "missing section of the lung in which gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgfbr1R244Q/Tgfbr1+
Genetic Background: either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lmnb1tm1.2Sgy/Lmnb1tm1.2Sgy
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012174 flat head "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [MGI:anna]
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Allelic Composition: Lmnb1tm2Sgy/Lmnb1tm2Sgy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024590 Lmnb1 / P14733 / Lamin-B1 / P20700*  / complex
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / reaction
 ENSMUSG00000027997 Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*  / reaction






 

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