ENSMUSG00000026728


Mus musculus

Features
Gene ID: ENSMUSG00000026728
  
Biological name :Vim
  
Synonyms : P20152 / Vim / vimentin
  
Possible biological names infered from orthology : P08670
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 13573927
Gene end: 13582826
  
Corresponding Affymetrix probe sets: 10469322 (MoGene1.0st)   1438118_x_at (Mouse Genome 430 2.0 Array)   1450641_at (Mouse Genome 430 2.0 Array)   1456292_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028062
Ensembl peptide - ENSMUSP00000141494
Ensembl peptide - ENSMUSP00000114742
NCBI entrez gene - 22352     See in Manteia.
MGI - MGI:98932
RefSeq - NM_011701
RefSeq Peptide - NP_035831
swissprot - A0A0A6YWC8
swissprot - A2AKJ2
swissprot - P20152
swissprot - Q5FWJ3
Ensembl - ENSMUSG00000026728
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vimENSDARG00000010008Danio rerio
 vimlENSDARG00000044501Danio rerio
 VIMENSGALG00000008677Gallus gallus
 VIMENSG00000026025Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Des / P31001 / Desmin / P17661*ENSMUSG0000002620863
Prph / peripherin / P41219*ENSMUSG0000002348457
Gfap / P03995 / Glial fibrillary acidic protein / P14136*ENSMUSG0000002093252
Ina / P46660 / internexin neuronal intermediate filament protein, alpha / Q16352*ENSMUSG0000003433647
Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*ENSMUSG0000002205544
Nefm / neurofilament medium / P07197*ENSMUSG0000002205441
Nefh / P19246 / Neurofilament heavy polypeptide / P12036* / neurofilament heavy*ENSMUSG0000002039638
Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*ENSMUSG0000002806326
Lmnb2 / P21619 / Lamin-B2 / Q03252*ENSMUSG0000006207526
Lmnb1 / P14733 / Lamin-B1 / P20700*ENSMUSG0000002459025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR006821  Intermediate filament head, DNA-binding domain
 IPR018039  Intermediate filament protein, conserved site
 IPR027699  Vimentin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010977 negative regulation of neuron projection development IGI
 biological_processGO:0014002 astrocyte development IGI
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0045103 intermediate filament-based process IMP
 biological_processGO:0045109 intermediate filament organization IGI
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IMP
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0070307 lens fiber cell development IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0045098 type III intermediate filament TAS
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005212 structural constituent of eye lens IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:1990254 keratin filament binding IEA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vimtm2Cba/Vimtm2Cba
Genetic Background: involves: 129S2/SvPas

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Vimtm2Cba/Vimtm2Cba
Genetic Background: involves: 129S2/SvPas

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm4Ito/Gfaptm4Ito
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm4Ito/Gfaptm4Ito,Vimtm1Cba/Vimtm1Cba
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Vimtm2Cba/Vimtm2Cba
Genetic Background: involves: 129S2/SvPas

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003627 abnormal lymphocyte rolling "anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Vimtm2Cba/Vimtm2Cba
Genetic Background: involves: 129S2/SvPas

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0012506 brain atrophy "acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025076 Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*  / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction
 ENSMUSG00000027997 Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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