ENSMUSG00000027997


Mus musculus

Features
Gene ID: ENSMUSG00000027997
  
Biological name :Casp6
  
Synonyms : Casp6 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / O08738
  
Possible biological names infered from orthology : caspase 6 / P55212
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 129901425
Gene end: 129914103
  
Corresponding Affymetrix probe sets: 10496023 (MoGene1.0st)   1415995_at (Mouse Genome 430 2.0 Array)   1458715_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029626
NCBI entrez gene - 12368     See in Manteia.
MGI - MGI:1312921
RefSeq - NM_009811
RefSeq Peptide - NP_033941
swissprot - O08738
swissprot - Q3TPJ9
Ensembl - ENSMUSG00000027997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp6ENSDARG00000093405Danio rerio
 casp6l1ENSDARG00000025608Danio rerio
 casp6l2ENSDARG00000070368Danio rerio
 CASP6ENSGALG00000012186Gallus gallus
 CASP6ENSG00000138794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*ENSMUSG0000003162838
Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*ENSMUSG0000002507636
Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*ENSMUSG0000002602935
Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*ENSMUSG0000002891432
Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*ENSMUSG0000002986326
Casp14 / O89094 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / P31...ENSMUSG0000000535525
Casp16-ps / caspase 16, apoptosis-related cysteine peptidase, pseudogeneENSMUSG0000006788215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR037554  Caspase-6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis RCA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0072734 cellular response to staurosporine IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity RCA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Casp6tm1.2Xen/Casp6+
Genetic Background: FVB.B6NTac-Casp6tm1.2Xen

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv
Genetic Background: B6.129S1-Casp3tm1Flv

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Casp6tm1.2Xen/Casp6+
Genetic Background: FVB.B6NTac-Casp6tm1.2Xen

 MP:0010259 anterior polar cataracts "a lens opacity, usually disk-shaped, that is limited to an area in the anterior pole of the lens capsular region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012467 increased striatum area "greater size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
Show

Allelic Composition: Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj,Gabra6tm2(cre)Wwis/Gabra6+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Casp6tm1.2Xen/Casp6+
Genetic Background: FVB.B6NTac-Casp6tm1.2Xen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027997 Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*  / complex
 ENSMUSG00000023927 Satb1 / Q60611 / Mus musculus special AT-rich sequence binding protein 1 (Satb1), transcript variant 5, mRNA. / Q01826* / SATB homeobox 1*  / reaction
 ENSMUSG00000028063 Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*  / reaction
 ENSMUSG00000024590 Lmnb1 / P14733 / Lamin-B1 / P20700*  / reaction
 ENSMUSG00000026728 Vim / P20152 / vimentin / P08670*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr