ENSMUSG00000023927


Mus musculus

Features
Gene ID: ENSMUSG00000023927
  
Biological name :Satb1
  
Synonyms : Mus musculus special AT-rich sequence binding protein 1 (Satb1), transcript variant 5, mRNA. / Q60611 / Satb1
  
Possible biological names infered from orthology : Q01826 / SATB homeobox 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 51736187
Gene end: 51833290
  
Corresponding Affymetrix probe sets: 10451763 (MoGene1.0st)   1416007_at (Mouse Genome 430 2.0 Array)   1416008_at (Mouse Genome 430 2.0 Array)   1436182_at (Mouse Genome 430 2.0 Array)   1439315_at (Mouse Genome 430 2.0 Array)   1439449_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121224
Ensembl peptide - ENSMUSP00000120536
Ensembl peptide - ENSMUSP00000123409
Ensembl peptide - ENSMUSP00000134957
Ensembl peptide - ENSMUSP00000128841
Ensembl peptide - ENSMUSP00000116006
Ensembl peptide - ENSMUSP00000116020
Ensembl peptide - ENSMUSP00000116639
Ensembl peptide - ENSMUSP00000118839
Ensembl peptide - ENSMUSP00000119842
NCBI entrez gene - 20230     See in Manteia.
MGI - MGI:105084
RefSeq - XM_017317366
RefSeq - NM_009122
RefSeq - XM_006523923
RefSeq - XM_006523924
RefSeq - XM_006523925
RefSeq - XM_006523926
RefSeq - XM_006523927
RefSeq - XM_006523928
RefSeq - XM_006523929
RefSeq - XM_017317363
RefSeq - XM_017317364
RefSeq - XM_017317365
RefSeq - NM_001163630
RefSeq - NM_001163631
RefSeq - NM_001163632
RefSeq - NM_001357637
RefSeq - NM_001357638
RefSeq Peptide - NP_001157103
RefSeq Peptide - NP_001157104
RefSeq Peptide - NP_001344566
RefSeq Peptide - NP_001344567
RefSeq Peptide - NP_033148
RefSeq Peptide - NP_001157102
swissprot - D3Z4F8
swissprot - D3YZD1
swissprot - E9PVB7
swissprot - Q60611
swissprot - D3YU76
Ensembl - ENSMUSG00000023927
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 satb1bENSDARG00000062621Danio rerio
 SATB1ENSGALG00000011254Gallus gallus
 SATB1ENSG00000182568Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Satb2 / Q8VI24 / special AT-rich sequence binding protein 2 / Q9UPW6* / SATB homeobox 2*ENSMUSG0000003833160


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR032355  SATB, CUT1-like DNA-binding domain
 IPR032392  SATB, ubiquitin-like oligomerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006325 chromatin organization IDA
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0043367 CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0050798 activated T cell proliferation IMP
 biological_processGO:0060004 reflex IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
SUMOylation of chromatin organization proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Prom2tm1.1(KOMP)Vlcg/Prom2+
Genetic Background: C57BL/6N-Prom2tm1.1(KOMP)Vlcg/J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Satb1tm1a(EUCOMM)Hmgu/Satb1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relnm1Anu/Relnm1Anu
Genetic Background: C57BL/6JAnu-Relnm1Anu

Allelic Composition: Satb1m1Anu/Satb1+
Genetic Background: C57L/6JAnu-Satb1m1Anu

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prom2tm1.1(KOMP)Vlcg/Prom2+
Genetic Background: C57BL/6N-Prom2tm1.1(KOMP)Vlcg/J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Satb1tm1a(EUCOMM)Hmgu/Satb1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Relnm1Anu/Relnm1Anu
Genetic Background: C57BL/6JAnu-Relnm1Anu

Allelic Composition: Satb1m1Anu/Satb1+
Genetic Background: C57L/6JAnu-Satb1m1Anu

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Satb1tm1a(EUCOMM)Hmgu/Satb1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027997 Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction






 

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