ENSMUSG00000005355


Mus musculus

Features
Gene ID: ENSMUSG00000005355
  
Biological name :Casp14
  
Synonyms : Casp14 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / O89094
  
Possible biological names infered from orthology : caspase 14 / P31944
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 78711991
Gene end: 78718294
  
Corresponding Affymetrix probe sets: 10370522 (MoGene1.0st)   1418748_at (Mouse Genome 430 2.0 Array)   1443787_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005488
Ensembl peptide - ENSMUSP00000151657
NCBI entrez gene - 12365     See in Manteia.
MGI - MGI:1335092
RefSeq - XM_006513160
RefSeq - NM_009809
RefSeq Peptide - NP_033939
swissprot - O89094
swissprot - Q542Q1
Ensembl - ENSMUSG00000005355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CASP14ENSG00000105141Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*ENSMUSG0000003162829
Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*ENSMUSG0000002891428
Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*ENSMUSG0000002507628
Casp2 / P29594 / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12 / P42575* / caspase 2*ENSMUSG0000002986327
Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*ENSMUSG0000002602926
Casp6 / O08738 / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11 / P55212* / caspase 6*ENSMUSG0000002799726
Casp16-ps / caspase 16, apoptosis-related cysteine peptidase, pseudogeneENSMUSG0000006788223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR033174  Caspase-14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis RCA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0070268 cornification IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0045095 keratin filament IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity TAS
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
Show

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001203 skin irradiation sensitivity "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
Show

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005355 Casp14 / O89094 / Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form / P31...  / complex






 

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