ENSMUSG00000062075


Mus musculus

Features
Gene ID: ENSMUSG00000062075
  
Biological name :Lmnb2
  
Synonyms : Lamin-B2 / Lmnb2 / P21619
  
Possible biological names infered from orthology : Q03252
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80901203
Gene end: 80918245
  
Corresponding Affymetrix probe sets: 10371012 (MoGene1.0st)   1448531_at (Mouse Genome 430 2.0 Array)   1451849_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057291
Ensembl peptide - ENSMUSP00000100969
Ensembl peptide - ENSMUSP00000136524
NCBI entrez gene - 16907     See in Manteia.
MGI - MGI:96796
RefSeq - XM_006513278
RefSeq - NM_010722
RefSeq Peptide - NP_001334069
RefSeq Peptide - NP_034852
swissprot - P21619
swissprot - Q3V159
swissprot - A0A0R4J0Q5
Ensembl - ENSMUSG00000062075
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmnb2ENSDARG00000101624Danio rerio
 LMNB2ENSGALG00000000470Gallus gallus
 LMNB2ENSG00000176619Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmnb1 / P14733 / Lamin-B1 / P20700*ENSMUSG0000002459056
Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*ENSMUSG0000002806353
Nefm / neurofilament medium / P07197*ENSMUSG0000002205422
Prph / peripherin / P41219*ENSMUSG0000002348421
Gfap / P03995 / Glial fibrillary acidic protein / P14136*ENSMUSG0000002093221
Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*ENSMUSG0000002205521
Des / P31001 / Desmin / P17661*ENSMUSG0000002620821
Vim / P20152 / vimentin / P08670*ENSMUSG0000002672821
Nefh / P19246 / Neurofilament heavy polypeptide / P12036* / neurofilament heavy*ENSMUSG0000002039621
Ina / P46660 / internexin neuronal intermediate filament protein, alpha / Q16352*ENSMUSG0000003433620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001322  Lamin tail domain
 IPR001664  Intermediate filament protein
 IPR018039  Intermediate filament protein, conserved site
 IPR036415  Lamin tail domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005638 lamin filament IDA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgfbr1R244Q/Tgfbr1+
Genetic Background: either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0009718 absent Purkinje cell layer "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Lmnb1tm1Yxz/Lmnb1tm1Yxz,Lmnb2tm1Yxz/Lmnb2tm1Yxz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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