ENSDARG00000102328


Danio rerio

Features
Gene ID: ENSDARG00000102328
  
Biological name :raf1a
  
Synonyms : raf1a / Raf-1 proto-oncogene, serine/threonine kinase a
  
Possible biological names infered from orthology : Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049 / Q99N57 / RAF1 / Raf-1 proto-oncogene, serine/threonine kinase
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 4709744
Gene end: 4717643
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130228
swissprot - A0A0G2KD64
ZFIN ID - ZDB-GENE-990415-41
Ensembl - ENSDARG00000102328
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAF1ENSGALG00000004998Gallus gallus
 RAF1ENSG00000132155Homo sapiens
 Raf1ENSMUSG00000000441Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
raf1a / Raf-1 proto-oncogene, serine/threonine kinase a / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG00000096415100
raf1b / Raf-1 proto-oncogene, serine/threonine kinase b / RAF1* / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), trans...ENSDARG0000005940679
araf / A-Raf proto-oncogene, serine/threonine kinase / P04627* / P10398* / Serine/threonine-protein kinase A-Raf *ENSDARG0000005453353
braf / B-Raf proto-oncogene, serine/threonine kinase / P15056* / P28028* / Serine/threonine-protein kinase B-raf *ENSDARG0000001766149
ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSDARG0000009452622
ksr1a / kinase suppressor of ras 1a / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000006871421
ksr1b / kinase suppressor of ras 1b / KSR1* / Q61097* / Q8IVT5* / kinase suppressor of ras 1* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSDARG0000003093321
si:ch73-263f13.1 / KSR2* / Q6VAB6* / kinase suppressor of ras 2*ENSDARG000000941723


Protein motifs (from Interpro)
Interpro ID Name
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rap1 signalling
GP1b-IX-V activation signalling
CREB phosphorylation through the activation of Ras
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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