ENSMUSG00000032959


Mus musculus

Features
Gene ID: ENSMUSG00000032959
  
Biological name :Pebp1
  
Synonyms : P70296 / Pebp1 / phosphatidylethanolamine binding protein 1
  
Possible biological names infered from orthology : P30086
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 117282654
Gene end: 117287625
  
Corresponding Affymetrix probe sets: 10362359 (MoGene1.0st)   10466439 (MoGene1.0st)   10533085 (MoGene1.0st)   1415950_a_at (Mouse Genome 430 2.0 Array)   1438649_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048425
Ensembl peptide - ENSMUSP00000116186
Ensembl peptide - ENSMUSP00000107604
NCBI entrez gene - 23980     See in Manteia.
MGI - MGI:1344408
RefSeq - NM_018858
RefSeq Peptide - NP_061346
swissprot - D3Z1V4
swissprot - D6RHS6
swissprot - P70296
swissprot - Q5EBQ2
Ensembl - ENSMUSG00000032959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pebp1ENSDARG00000042069Danio rerio
 PEBP1ENSGALG00000007403Gallus gallus
 PEBP1ENSG00000089220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pbp2 / PEBP1* / P30086* / phosphatidylethanolamine binding protein 1*ENSMUSG0000004710479
Pebp4 / Q96S96* / phosphatidylethanolamine binding protein 4*ENSMUSG0000002208531


Protein motifs (from Interpro)
Interpro ID Name
 IPR001858  Phosphatidylethanolamine-binding, conserved site
 IPR008914  Phosphatidylethanolamine-binding protein
 IPR035810  Phosphatidylethanolamine-binding protein, eukaryotic
 IPR036610  PEBP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001505 regulation of neurotransmitter levels IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0048240 sperm capacitation IDA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060409 positive regulation of acetylcholine metabolic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pycardtm1Flv/Pycardtm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Pycardtm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex






 

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