ENSG00000089220


Homo sapiens

Features
Gene ID: ENSG00000089220
  
Biological name :PEBP1
  
Synonyms : P30086 / PEBP1 / phosphatidylethanolamine binding protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.23
Gene start: 118135858
Gene end: 118145584
  
Corresponding Affymetrix probe sets: 205353_s_at (Human Genome U133 Plus 2.0 Array)   210825_s_at (Human Genome U133 Plus 2.0 Array)   211941_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261313
NCBI entrez gene - 5037     See in Manteia.
OMIM - 604591
RefSeq - NM_002567
RefSeq Peptide - NP_002558
swissprot - D9IAI1
swissprot - P30086
Ensembl - ENSG00000089220
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pebp1ENSDARG00000042069Danio rerio
 PEBP1ENSGALG00000007403Gallus gallus
 Pbp2ENSMUSG00000047104Mus musculus
 Pebp1ENSMUSG00000032959Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PEBP4 / Q96S96 / phosphatidylethanolamine binding protein 4ENSG0000013402029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001858  Phosphatidylethanolamine-binding, conserved site
 IPR008914  Phosphatidylethanolamine-binding protein
 IPR035810  Phosphatidylethanolamine-binding protein, eukaryotic
 IPR036610  PEBP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction / complex
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex






 

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