ENSMUSG00000024427


Mus musculus

Features
Gene ID: ENSMUSG00000024427
  
Biological name :Spry4
  
Synonyms : 4 / Q9WTP2 / Spry4
  
Possible biological names infered from orthology : Q9C004 / sprouty RTK signaling antagonist 4
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 38586268
Gene end: 38601268
  
Corresponding Affymetrix probe sets: 10458555 (MoGene1.0st)   1422020_at (Mouse Genome 430 2.0 Array)   1422021_at (Mouse Genome 430 2.0 Array)   1440867_at (Mouse Genome 430 2.0 Array)   1445669_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025295
NCBI entrez gene - 24066     See in Manteia.
MGI - MGI:1345144
RefSeq - NM_011898
RefSeq Peptide - NP_036028
swissprot - Q9WTP2
Ensembl - ENSMUSG00000024427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spry4ENSDARG00000068732Danio rerio
 SPRY4ENSGALG00000033012Gallus gallus
 SPRY4ENSG00000187678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spry1 / Q9QXV9 / sprouty RTK signaling antagonist 1 / O43609*ENSMUSG0000003721139
Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*ENSMUSG0000002211438


Protein motifs (from Interpro)
Interpro ID Name
 IPR007875  Sprouty
 IPR030790  Protein sprouty homologue 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic Background: involves: 129 * CD-1

 MP:0004083 polysyndactyly "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Wnt1tm1Amc/Wnt1tm1Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2+,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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