ENSMUSG00000040525


Mus musculus

Features
Gene ID: ENSMUSG00000040525
  
Biological name :Cblc
  
Synonyms : Cblc / E3 ubiquitin-protein ligase CBL-C / Q80XL1
  
Possible biological names infered from orthology : Cbl proto-oncogene C / Q9ULV8
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19778881
Gene end: 19796809
  
Corresponding Affymetrix probe sets: 10560672 (MoGene1.0st)   1422666_at (Mouse Genome 430 2.0 Array)   1431692_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039955
Ensembl peptide - ENSMUSP00000104088
NCBI entrez gene - 80794     See in Manteia.
MGI - MGI:1931457
RefSeq - NM_001161844
RefSeq - NM_023224
RefSeq Peptide - NP_001155316
RefSeq Peptide - NP_075713
swissprot - Q80XL1
swissprot - G3X9U0
Ensembl - ENSMUSG00000040525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cblcENSDARG00000078217Danio rerio
 CBLCENSG00000142273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cblb / Q3TTA7 / E3 ubiquitin-protein ligase CBL-B / Q13191* / Cbl proto-oncogene B*ENSMUSG0000002263744
Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*ENSMUSG0000003434243


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl
 IPR036537  Adaptor protein Cbl, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0023051 regulation of signaling IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 cellular_componentGO:0000151 ubiquitin ligase complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvrl1tm1Spo/Acvrl1tm1Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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