ENSG00000142273


Homo sapiens

Features
Gene ID: ENSG00000142273
  
Biological name :CBLC
  
Synonyms : CBLC / Cbl proto-oncogene C / Q9ULV8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 44777869
Gene end: 44800634
  
Corresponding Affymetrix probe sets: 220638_s_at (Human Genome U133 Plus 2.0 Array)   223668_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000270279
Ensembl peptide - ENSP00000340250
Ensembl peptide - ENSP00000494162
Ensembl peptide - ENSP00000495258
NCBI entrez gene - 23624     See in Manteia.
OMIM - 608453
RefSeq - XM_011526689
RefSeq - NM_001130852
RefSeq - NM_012116
RefSeq - XM_005258696
RefSeq - XM_011526688
RefSeq Peptide - NP_001124324
RefSeq Peptide - NP_036248
swissprot - Q9ULV8
Ensembl - ENSG00000142273
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cblcENSDARG00000078217Danio rerio
 CblcENSMUSG00000040525Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBLB / Q13191 / Cbl proto-oncogene BENSG0000011442346
CBL / P22681 / Cbl proto-oncogeneENSG0000011039545


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl
 IPR036537  Adaptor protein Cbl, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0023051 regulation of signaling IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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