ENSG00000114423


Homo sapiens

Features
Gene ID: ENSG00000114423
  
Biological name :CBLB
  
Synonyms : CBLB / Cbl proto-oncogene B / Q13191
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q13.11
Gene start: 105655461
Gene end: 105869552
  
Corresponding Affymetrix probe sets: 208348_s_at (Human Genome U133 Plus 2.0 Array)   209682_at (Human Genome U133 Plus 2.0 Array)   227900_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000496297
Ensembl peptide - ENSP00000495754
Ensembl peptide - ENSP00000496352
Ensembl peptide - ENSP00000496761
Ensembl peptide - ENSP00000496708
Ensembl peptide - ENSP00000264122
Ensembl peptide - ENSP00000377598
Ensembl peptide - ENSP00000384816
Ensembl peptide - ENSP00000384938
Ensembl peptide - ENSP00000393906
Ensembl peptide - ENSP00000400949
Ensembl peptide - ENSP00000409750
Ensembl peptide - ENSP00000494262
Ensembl peptide - ENSP00000494383
Ensembl peptide - ENSP00000494989
NCBI entrez gene - 868     See in Manteia.
OMIM - 604491
RefSeq - NM_001321795
RefSeq - NM_001321789
RefSeq - NM_001321790
RefSeq - NM_001321791
RefSeq - NM_001321793
RefSeq - NM_001321794
RefSeq - NM_001321796
RefSeq - NM_001321797
RefSeq - NM_001321798
RefSeq - NM_001321799
RefSeq - NM_001321806
RefSeq - NM_001321807
RefSeq - NM_001321808
RefSeq - NM_001321811
RefSeq - NM_001321813
RefSeq - NM_001321816
RefSeq - NM_001321820
RefSeq - NM_001321822
RefSeq - NM_170662
RefSeq - XM_011513257
RefSeq - XM_011513259
RefSeq - XM_017007395
RefSeq - XM_017007396
RefSeq - XM_017007397
RefSeq - XM_017007398
RefSeq - XM_017007399
RefSeq - XM_017007400
RefSeq - NM_001321786
RefSeq - NM_001321788
RefSeq Peptide - NP_001308718
RefSeq Peptide - NP_001308749
RefSeq Peptide - NP_001308751
RefSeq Peptide - NP_733762
RefSeq Peptide - NP_001308715
RefSeq Peptide - NP_001308717
RefSeq Peptide - NP_001308719
RefSeq Peptide - NP_001308720
RefSeq Peptide - NP_001308722
RefSeq Peptide - NP_001308723
RefSeq Peptide - NP_001308724
RefSeq Peptide - NP_001308725
RefSeq Peptide - NP_001308726
RefSeq Peptide - NP_001308727
RefSeq Peptide - NP_001308728
RefSeq Peptide - NP_001308735
RefSeq Peptide - NP_001308736
RefSeq Peptide - NP_001308737
RefSeq Peptide - NP_001308740
RefSeq Peptide - NP_001308742
RefSeq Peptide - NP_001308745
swissprot - C9JRB3
swissprot - Q68CY2
swissprot - C9JU85
swissprot - Q13191
swissprot - B5MC15
Ensembl - ENSG00000114423
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cblbENSDARG00000015199Danio rerio
 CBLBENSGALG00000015351Gallus gallus
 CblbENSMUSG00000022637Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBL / P22681 / Cbl proto-oncogeneENSG0000011039547
CBLC / Q9ULV8 / Cbl proto-oncogene CENSG0000014227322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR015940  Ubiquitin-associated domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl
 IPR036537  Adaptor protein Cbl, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006607 NLS-bearing protein import into nucleus TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0023051 regulation of signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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