ENSMUSG00000022637


Mus musculus

Features
Gene ID: ENSMUSG00000022637
  
Biological name :Cblb
  
Synonyms : Cblb / E3 ubiquitin-protein ligase CBL-B / Q3TTA7
  
Possible biological names infered from orthology : Cbl proto-oncogene B / Q13191
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B5
Gene start: 52031225
Gene end: 52208048
  
Corresponding Affymetrix probe sets: 10436209 (MoGene1.0st)   1437304_at (Mouse Genome 430 2.0 Array)   1455082_at (Mouse Genome 430 2.0 Array)   1458469_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153753
Ensembl peptide - ENSMUSP00000154583
Ensembl peptide - ENSMUSP00000154755
Ensembl peptide - ENSMUSP00000110115
Ensembl peptide - ENSMUSP00000153787
NCBI entrez gene - 208650     See in Manteia.
MGI - MGI:2146430
RefSeq - XM_006521952
RefSeq - NM_001033238
RefSeq - XM_006521949
RefSeq - XM_006521950
RefSeq - XM_006521951
RefSeq - XM_006521947
RefSeq - XM_006521948
RefSeq Peptide - NP_001028410
swissprot - Q3TTA7
swissprot - B9EKI5
Ensembl - ENSMUSG00000022637
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cblbENSDARG00000015199Danio rerio
 CBLBENSGALG00000015351Gallus gallus
 CBLBENSG00000114423Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*ENSMUSG0000003434249
Cblc / Q80XL1 / E3 ubiquitin-protein ligase CBL-C / Q9ULV8* / Cbl proto-oncogene C*ENSMUSG0000004052523


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR015940  Ubiquitin-associated domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl
 IPR036537  Adaptor protein Cbl, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002669 positive regulation of T cell anergy IMP
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0023051 regulation of signaling IEA
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0046642 negative regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0050856 regulation of T cell receptor signaling pathway ISO
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr
Genetic Background: involves: 129 * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: BALB/c

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua,Ubash3btm1Jni/Ubash3btm1Jni,Ubash3atm1Jni/Ubash3atm1Jni
Genetic Background: Not Specified

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua
Genetic Background: B6.129P2-Cblbtm1Hua

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua,Ubash3btm1Jni/Ubash3btm1Jni,Ubash3atm1Jni/Ubash3atm1Jni
Genetic Background: Not Specified

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua
Genetic Background: Not Specified

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua
Genetic Background: B6.129P2-Cblbtm1Hua

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr
Genetic Background: B6.129P2-Cblbtm1Pngr

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbltm2Hua/Cbltm2Hua,Cblbtm1Hua/Cblbtm1Hua,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr
Genetic Background: involves: 129 * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua
Genetic Background: B6.129P2-Cblbtm1Hua

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr