ENSDARG00000015199


Danio rerio

Features
Gene ID: ENSDARG00000015199
  
Biological name :cblb
  
Synonyms : alcama / cblb / Cbl proto-oncogene B, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : Cbl proto-oncogene B / E3 ubiquitin-protein ligase CBL-B / Q13191 / Q3TTA7
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 28587446
Gene end: 28733002
  
Corresponding Affymetrix probe sets: Dr.14521.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000033942
Ensembl peptide - ENSDARP00000116090
NCBI entrez gene - 556277     See in Manteia.
swissprot - F1Q742
swissprot - F1R6A7
ZFIN ID - ZDB-GENE-030616-417
ZFIN ID - ZDB-GENE-990415-30
Ensembl - ENSDARG00000015199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CBLBENSGALG00000015351Gallus gallus
 CBLBENSG00000114423Homo sapiens
 CblbENSMUSG00000022637Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cbl / Cbl proto-oncogene, E3 ubiquitin protein ligase / P22682* / P22681* / Cbl proto-oncogene* / E3 ubiquitin-protein ligase CBL *ENSDARG0000000995847
cblc / Cbl proto-oncogene C, E3 ubiquitin protein ligase / Q9ULV8* / Q80XL1* / Cbl proto-oncogene C* / E3 ubiquitin-protein ligase CBL-C *ENSDARG0000007821728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR015940  Ubiquitin-associated domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0023051 regulation of signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer morphology , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer nucleus apoptotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000076 swim bladder swim bladder absent , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye mislocalised ventrally , abnormal
eye decreased diameter , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer neuron decreased amount , abnormal
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 ZFA:0000368 integument integument melanocyte spatial pattern , abnormal
integument melanocyte decreased contractility , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased thickness , abnormal
cranial nerve II aplastic , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001106 pharyngeal pouch pharyngeal pouch malformed , abnormal
pharyngeal pouch adherens junction organization process quality , abnormal
pharyngeal pouch apical protein localization decreased occurrence , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage bent , abnormal
Meckels cartilage fused with palatoquadrate cartilage , abnormal
Meckels cartilage protruding , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium decreased length , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
ventral mandibular arch decreased length , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage fused with hyosymplectic cartilage , abnormal
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 ZFA:0001511 interhyal cartilage interhyal cartilage absent , abnormal
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 ZFA:0001625 optic nerve head optic nerve head decreased size , abnormal
optic nerve head axon absent , abnormal
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 ZFA:0001655 pericardial cavity pericardial cavity increased size , abnormal
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 ZFA:0009255 amacrine cell amacrine cell decreased amount , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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