ENSDARG00000009958


Danio rerio

Features
Gene ID: ENSDARG00000009958
  
Biological name :cbl
  
Synonyms : cbl / Cbl proto-oncogene, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : Cbl proto-oncogene / E3 ubiquitin-protein ligase CBL / P22681 / P22682
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 23208042
Gene end: 23265405
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000027963
NCBI entrez gene - 492364     See in Manteia.
RefSeq - NM_001007330
RefSeq - XM_005157579
RefSeq Peptide - NP_001007331
swissprot - F1QI90
ZFIN ID - ZDB-GENE-041114-207
Ensembl - ENSDARG00000009958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CBLENSGALG00000029077Gallus gallus
 CBLENSG00000110395Homo sapiens
 CblENSMUSG00000034342Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cblb / alcama / Cbl proto-oncogene B, E3 ubiquitin protein ligase / Q3TTA7* / Q13191* / Cbl proto-oncogene B* / E3 ubiquitin-protein ligase CBL-B *ENSDARG0000001519948
cblc / Cbl proto-oncogene C, E3 ubiquitin protein ligase / Q9ULV8* / Q80XL1* / Cbl proto-oncogene C* / E3 ubiquitin-protein ligase CBL-C *ENSDARG0000007821729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001841  Zinc finger, RING-type
 IPR003153  Adaptor protein Cbl, N-terminal helical
 IPR009060  UBA-like superfamily
 IPR011992  EF-hand domain pair
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014741  Adaptor protein Cbl, EF hand-like
 IPR014742  Adaptor protein Cbl, SH2-like domain
 IPR015940  Ubiquitin-associated domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR024159  Adaptor protein Cbl, PTB domain
 IPR024162  Adaptor protein Cbl


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0023051 regulation of signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0045121 membrane raft IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0017124 SH3 domain binding IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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