ENSMUSG00000074695


Mus musculus

Features
Gene ID: ENSMUSG00000074695
  
Biological name :Il22
  
Synonyms : Il22 / Interleukin-22 / Q9JJY9
  
Possible biological names infered from orthology : Q9GZX6
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 118204942
Gene end: 118210047
  
Corresponding Affymetrix probe sets: 10366572 (MoGene1.0st)   10373695 (MoGene1.0st)   1427624_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094449
NCBI entrez gene - 50929     See in Manteia.
MGI - MGI:1355307
RefSeq - NM_016971
RefSeq - XM_006513865
RefSeq Peptide - NP_058667
swissprot - Q9JJY9
Ensembl - ENSMUSG00000074695
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL22ENSGALG00000009904Gallus gallus
 IL22ENSG00000127318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*ENSMUSG0000009046198


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR020423  Interleukin-10, conserved site
 IPR020453  Interleukin-22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001655 multifocal hepatic necrosis "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tno/Apc+,Il23rtm1.2Trin/Il23rtm1.2Trin,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J

Allelic Composition: Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008639 decreased circulating interleukin-1 alpha level "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

Allelic Composition: Il22tm1Flv/Il22+
Genetic Background: B6.Cg-Il22tm1Flv

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Sh2d1arpl/Sh2d1arpl
Genetic Background: MRL/Mp-Faslpr Sh2d1arpl

Allelic Composition: Il22tm1Flv/Il22+
Genetic Background: B6.Cg-Il22tm1Flv

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0012424 decreased alimentary system tumor incidence "less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0020186 altered susceptibility to bacterial infection "a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [GOC:NV]
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037157 Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*  / reaction / complex
 ENSMUSG00000039760 Q80XF5 / Il22ra2 / Interleukin-22 receptor subunit alpha-2 / Q969J5*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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