ENSMUSG00000039760


Mus musculus

Features
Gene ID: ENSMUSG00000039760
  
Biological name :Il22ra2
  
Synonyms : Il22ra2 / Interleukin-22 receptor subunit alpha-2 / Q80XF5
  
Possible biological names infered from orthology : Q969J5
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A3
Gene start: 19621998
Gene end: 19634681
  
Corresponding Affymetrix probe sets: 10361906 (MoGene1.0st)   1437665_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042642
NCBI entrez gene - 237310     See in Manteia.
MGI - MGI:2665114
RefSeq - NM_178258
RefSeq Peptide - NP_839989
swissprot - Q80XF5
Ensembl - ENSMUSG00000039760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il22ra2ENSDARG00000039439Danio rerio
 Q969J5ENSG00000164485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*ENSMUSG0000003715730
Il20ra / Q6PHB0 / interleukin 20 receptor, alpha / Q9UHF4* / interleukin 20 receptor subunit alpha*ENSMUSG0000002000728


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042017 interleukin-22 binding IEA
 molecular_functionGO:0042018 interleukin-22 receptor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apctm1Tno/Apc+,Il23rtm1.2Trin/Il23rtm1.2Trin,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Tno/Apc+,Il23rtm1.2Trin/Il23rtm1.2Trin,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J

Allelic Composition: ApcMin/Apc+,Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tno/Apc+,Il23rtm1.2Trin/Il23rtm1.2Trin,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J

Allelic Composition: Il22tm1Flv/Il22tm1Flv,Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tno/Apc+,Il23rtm1.2Trin/Il23rtm1.2Trin,Tg(CDX2-cre)101Erf/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074695 Il22 / Q9JJY9 / Interleukin-22 / Q9GZX6*  / reaction / complex
 ENSMUSG00000090461 Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*  / complex / reaction






 

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