ENSMUSG00000020007


Mus musculus

Features
Gene ID: ENSMUSG00000020007
  
Biological name :Il20ra
  
Synonyms : Il20ra / interleukin 20 receptor, alpha / Q6PHB0
  
Possible biological names infered from orthology : interleukin 20 receptor subunit alpha / Q9UHF4
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A3
Gene start: 19712570
Gene end: 19760053
  
Corresponding Affymetrix probe sets: 10361918 (MoGene1.0st)   1446498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020185
Ensembl peptide - ENSMUSP00000150417
NCBI entrez gene - 237313     See in Manteia.
MGI - MGI:3605069
RefSeq - XM_011243169
RefSeq - NM_172786
RefSeq - XM_006512726
RefSeq Peptide - NP_766374
swissprot - Q6PHB0
swissprot - E6Y2L0
Ensembl - ENSMUSG00000020007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il20raENSDARG00000032571Danio rerio
 IL20RAENSGALG00000013869Gallus gallus
 IL20RAENSG00000016402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*ENSMUSG0000003715715
Q80XF5 / Il22ra2 / Interleukin-22 receptor subunit alpha-2 / Q969J5*ENSMUSG0000003976012


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR015713  Interleukin-20 receptor alpha
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0045124 regulation of bone resorption IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004896 cytokine receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042015 interleukin-20 binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2ho-20J/Grid2ho-20J
Genetic Background: B6(Cg)-Grid2ho-20J/GrsrJ

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Coro1atm1Achn/Coro1atm1Achn
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000016524 Il19 / Q8CJ70 / Interleukin-19 / Q9UHD0*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000026420 Il24 / interleukin 24 / Q13007*  / complex
 ENSMUSG00000044244 Il20rb / interleukin 20 receptor subunit beta / Q6UXL0*  / complex
 ENSMUSG00000026416 Il20 / Q9JKV9 / interleukin 20 / Q9NYY1*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr